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000178323 1001_ $$00000-0001-9601-2468$$aMao, Ziling$$b0
000178323 245__ $$aDietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer.
000178323 260__ $$aBasel$$bMDPI$$c2021
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000178323 520__ $$aAdvanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.
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000178323 650_7 $$2Other$$aadvanced glycation end-products
000178323 650_7 $$2Other$$aall-cause mortality
000178323 650_7 $$2Other$$acolorectal cancer mortality
000178323 650_7 $$2Other$$adietary advanced glycation end-products
000178323 7001_ $$aAglago, Elom K$$b1
000178323 7001_ $$aZhao, Zhiwei$$b2
000178323 7001_ $$aSchalkwijk, Casper$$b3
000178323 7001_ $$00000-0002-0237-0262$$aJiao, Li$$b4
000178323 7001_ $$00000-0001-8648-4998$$aFreisling, Heinz$$b5
000178323 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b6
000178323 7001_ $$00000-0003-1668-8770$$aHughes, David J$$b7
000178323 7001_ $$aEriksen, Anne Kirstine$$b8
000178323 7001_ $$aTjønneland, Anne$$b9
000178323 7001_ $$aSeveri, Gianluca$$b10
000178323 7001_ $$aRothwell, Joseph$$b11
000178323 7001_ $$aBoutron-Ruault, Marie-Christine$$b12
000178323 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b13$$udkfz
000178323 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b14$$udkfz
000178323 7001_ $$00000-0002-0830-5277$$aSchulze, Matthias B$$b15
000178323 7001_ $$00000-0002-8306-3351$$aBirukov, Anna$$b16
000178323 7001_ $$00000-0003-0122-8624$$aKrogh, Vittorio$$b17
000178323 7001_ $$aPanico, Salvatore$$b18
000178323 7001_ $$aTumino, Rosario$$b19
000178323 7001_ $$aRicceri, Fulvio$$b20
000178323 7001_ $$aBueno-de-Mesquita, H Bas$$b21
000178323 7001_ $$aVermeulen, Roel C H$$b22
000178323 7001_ $$00000-0002-0031-4152$$aGram, Inger T$$b23
000178323 7001_ $$00000-0003-2476-4251$$aSkeie, Guri$$b24
000178323 7001_ $$aSandanger, Torkjel M$$b25
000178323 7001_ $$aQuirós, J Ramón$$b26
000178323 7001_ $$aCrous-Bou, Marta$$b27
000178323 7001_ $$00000-0003-4817-0757$$aSánchez, Maria-Jose$$b28
000178323 7001_ $$aAmiano, Pilar$$b29
000178323 7001_ $$aChirlaque, María-Dolores$$b30
000178323 7001_ $$aBarricarte Gurrea, Aurelio$$b31
000178323 7001_ $$aManjer, Jonas$$b32
000178323 7001_ $$00000-0002-9227-8434$$aJohansson, Ingegerd$$b33
000178323 7001_ $$aPerez-Cornago, Aurora$$b34
000178323 7001_ $$00000-0002-0573-1852$$aJenab, Mazda$$b35
000178323 7001_ $$00000-0002-7805-9913$$aFedirko, Veronika$$b36
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