Journal Article

DKFZ-2021-03270

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer.

Mao, Z. ; Aglago, E. K. ; Zhao, Z. ; Schalkwijk, C. ; Jiao, L. ; Freisling, H. ; Weiderpass, E. ; Hughes, D. J. ; Eriksen, A. K. ; Tjønneland, A. ; Severi, G. ; Rothwell, J. ; Boutron-Ruault, M.-C. ; Katzke, V.DKFZ* ; Kaaks, R.DKFZ* ; Schulze, M. B. ; Birukov, A. ; Krogh, V. ; Panico, S. ; Tumino, R. ; Ricceri, F. ; Bueno-de-Mesquita, H. B. ; Vermeulen, R. C. H. ; Gram, I. T. ; Skeie, G. ; Sandanger, T. M. ; Quirós, J. R. ; Crous-Bou, M. ; Sánchez, M.-J. ; Amiano, P. ; Chirlaque, M.-D. ; Barricarte Gurrea, A. ; Manjer, J. ; Johansson, I. ; Perez-Cornago, A. ; Jenab, M. ; Fedirko, V.

2021
MDPI Basel

This record in other databases:  

Please use a persistent id in citations: doi:10.3390/nu13124435

Abstract: Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.

Keyword(s): advanced glycation end-products ; all-cause mortality ; colorectal cancer mortality ; dietary advanced glycation end-products

---

Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

---

Database coverage:
; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---