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@ARTICLE{Mao:178323,
      author       = {Z. Mao and E. K. Aglago and Z. Zhao and C. Schalkwijk and
                      L. Jiao and H. Freisling and E. Weiderpass and D. J. Hughes
                      and A. K. Eriksen and A. Tjønneland and G. Severi and J.
                      Rothwell and M.-C. Boutron-Ruault and V. Katzke$^*$ and R.
                      Kaaks$^*$ and M. B. Schulze and A. Birukov and V. Krogh and
                      S. Panico and R. Tumino and F. Ricceri and H. B.
                      Bueno-de-Mesquita and R. C. H. Vermeulen and I. T. Gram and
                      G. Skeie and T. M. Sandanger and J. R. Quirós and M.
                      Crous-Bou and M.-J. Sánchez and P. Amiano and M.-D.
                      Chirlaque and A. Barricarte Gurrea and J. Manjer and I.
                      Johansson and A. Perez-Cornago and M. Jenab and V. Fedirko},
      title        = {{D}ietary {I}ntake of {A}dvanced {G}lycation {E}nd
                      {P}roducts ({AGE}s) and {M}ortality among {I}ndividuals with
                      {C}olorectal {C}ancer.},
      journal      = {Nutrients},
      volume       = {13},
      number       = {12},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-03270},
      pages        = {4435},
      year         = {2021},
      abstract     = {Advanced glycation end-products (AGEs) may promote
                      oxidative stress and inflammation and have been linked to
                      multiple chronic diseases, including cancer. However, the
                      association of AGEs with mortality after colorectal cancer
                      (CRC) diagnosis has not been previously investigated.
                      Multivariable Cox proportional hazards models were used to
                      calculate hazard ratios and corresponding $95\%$ confidence
                      intervals for associations between dietary intake of AGEs
                      with CRC-specific and all-cause mortality among 5801
                      participant cases diagnosed with CRC in the European
                      Prospective Investigation into Cancer and Nutrition study
                      between 1993 and 2013. Dietary intakes of AGEs were
                      estimated using country-specific dietary questionnaires,
                      linked to an AGE database, that accounted for food
                      preparation and processing. During a median of 58 months of
                      follow-up, 2421 cases died (1841 from CRC). Individually or
                      combined, dietary intakes of AGEs were not associated with
                      all-cause and CRC-specific mortality among cases. However,
                      there was a suggestion for a positive association between
                      AGEs and all-cause or CRC-specific mortality among CRC cases
                      without type II diabetes (all-cause, Pinteraction = 0.05)
                      and CRC cases with the longest follow-up between recruitment
                      and cancer diagnosis (CRC-specific, Pinteraction = 0.003;
                      all-cause, Pinteraction = 0.01). Our study suggests that
                      pre-diagnostic dietary intakes of AGEs were not associated
                      with CRC-specific or all-cause mortality among CRC patients.
                      Further investigations using biomarkers of AGEs and
                      stratifying by sex, diabetes status, and timing of exposure
                      to AGEs are warranted.},
      keywords     = {advanced glycation end-products (Other) / all-cause
                      mortality (Other) / colorectal cancer mortality (Other) /
                      dietary advanced glycation end-products (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34959986},
      doi          = {10.3390/nu13124435},
      url          = {https://inrepo02.dkfz.de/record/178323},
}