Journal Article

DKFZ-2022-00366

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Value of APTw CEST MRI in Routine Clinical Assessment of Human Brain Tumor Patients at 3T.

Lingl, J. P. ; Wunderlich, A. ; Goerke, S.DKFZ* ; Paech, D.DKFZ* ; Ladd, M.DKFZ* ; Liebig, P. ; Pala, A. ; Kim, S. Y. ; Braun, M. ; Schmitz, B. L. ; Beer, M. ; Rosskopf, J.

2022
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/diagnostics12020490

Abstract: With fast-growing evidence in literature for clinical applications of chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI), this prospective study aimed at applying amide proton transfer-weighted (APTw) CEST imaging in a clinical setting to assess its diagnostic potential in differentiation of intracranial tumors at 3 tesla (T).Using the asymmetry magnetization transfer ratio (MTRasym) analysis, CEST signals were quantitatively investigated in the tumor areas and in a similar sized region of the normal-appearing white matter (NAWM) on the contralateral hemisphere of 27 patients with intracranial tumors. Area under curve (AUC) analyses were used and results were compared to perfusion-weighted imaging (PWI).Using APTw CEST, contrast-enhancing tumor areas showed significantly higher APTw CEST metrics than contralateral NAWM (AUC = 0.82; p < 0.01). In subgroup analyses of each tumor entity vs. NAWM, statistically significant effects were yielded for glioblastomas (AUC = 0.96; p < 0.01) and for meningiomas (AUC = 1.0; p < 0.01) but not for lymphomas as well as metastases (p > 0.05). PWI showed results comparable to APTw CEST in glioblastoma (p < 0.01).This prospective study confirmed the high diagnostic potential of APTw CEST imaging in a routine clinical setting to differentiate brain tumors.

Keyword(s): APTw ; CEST ; MRI ; brain tumor

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Contributing Institute(s):

1. E010 Radiologie (E010)
2. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2022

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