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@ARTICLE{Knig:179245,
      author       = {L. König$^*$ and A. Hommertgen$^*$ and L. Orschiedt and J.
                      Hörner-Rieber$^*$ and S. Brons and P. E. Huber$^*$ and J.
                      Debus$^*$ and S. Rieken$^*$},
      title        = {{I}nfluence of photon, proton and carbon ion irradiation on
                      differentiation, maturation and functionality of dendritic
                      cells.},
      journal      = {Frontiers in bioscience},
      volume       = {14},
      number       = {1},
      issn         = {1093-4715},
      address      = {Tampa, Fla.},
      reportid     = {DKFZ-2022-00527},
      pages        = {2},
      year         = {2022},
      note         = {#EA:E050#LA:E050#},
      abstract     = {While the primary purpose of radiotherapy (RT) is the
                      elimination of cancer cells by inducing DNA-damage,
                      considerable evidence emerges that anti-neoplastic effects
                      extend beyond mere tumor cell killing. These secondary
                      effects are based on activation of dendritic cells (DCs) via
                      induction of antitumoral immune reactions. However, there is
                      an ongoing debate whether or not irradiation of the DCs
                      themselves may negatively affect their maturation and
                      functionality. Human monocytes were irradiated with
                      different absorbed doses (1 × 15 Gy relative biological
                      effectiveness (RBE), 5 × 2 Gy (RBE), 1 × 0.5 Gy (RBE))
                      with photons, protons and carbon ions. Differentiation and
                      maturation of DCs were assessed by staining of corresponding
                      cell surface molecules and functional analysis of irradiated
                      DCs was based on in vitro analysis of phagocytosis,
                      migration and IL-12 secretion. Irradiation of CD14-positive
                      DCs did not alter surface phenotypes of immature DCs and
                      mature DCs. Not only differentiation, but also functionality
                      of immature DCs regarding phagocytosis, migration and IL-12
                      secretion capacity was not negatively influenced through RT
                      with photons, protons or carbon ions as well as with
                      different dose levels. After proton irradiation migratory
                      capacity of immature DCs was increased. Our experiments
                      reveal that phenotypic maturation of DCs remains unchanged
                      after RT with different fractionations and after irradiation
                      with particle therapy. Unaffected functionality
                      (phagocytosis, migration and cytokine secretion) after RT of
                      DCs indicated possible persistent potential for inducing
                      adaptive immune response. Additional effects on the
                      immunogenic potential of DCs will be investigated by further
                      functional assays.},
      keywords     = {Carbon ion (Other) / Dendritic cells (Other) / Maturation
                      (Other) / Monocyte derived (Other) / Monocytes (Other) /
                      Particle therapy (Other) / Phagocytosis (Other) / Protons
                      (Other) / Radioimmunology (Other) / Radiotherapy (Other)},
      cin          = {E050 / E055},
      ddc          = {610},
      cid          = {I:(DE-He78)E050-20160331 / I:(DE-He78)E055-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35320913},
      doi          = {10.31083/j.fbs1401002},
      url          = {https://inrepo02.dkfz.de/record/179245},
}