Journal Article

DKFZ-2022-00570

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Impact of Sub-Millisecond Damage Fixation Kinetics on the In Vitro Sparing Effect at Ultra-High Dose Rate in UNIVERSE.

Liew, H. (First author)DKFZ* ; Mein, S.DKFZ* ; Tessonnier, T.Extern* ; Abdollahi, A.DKFZ* ; Debus, J.DKFZ* ; Dokic, I.DKFZ* ; Mairani, A. (Last author)DKFZ*

2022
Molecular Diversity Preservation International Basel

This record in other databases:  

Please use a persistent id in citations: doi:10.3390/ijms23062954

Abstract: The impact of the exact temporal pulse structure on the potential cell and tissue sparing of ultra-high dose-rate irradiation applied in FLASH studies has gained increasing attention. A previous version of our biophysical mechanistic model (UNIVERSE: UNIfied and VERSatile bio response Engine), based on the oxygen depletion hypothesis, has been extended in this work by considering oxygen-dependent damage fixation dynamics on the sub-milliseconds scale and introducing an explicit implementation of the temporal pulse structure. The model successfully reproduces in vitro experimental data on the fast kinetics of the oxygen effect in irradiated mammalian cells. The implemented changes result in a reduction in the assumed amount of oxygen depletion. Furthermore, its increase towards conventional dose-rates is parameterized based on experimental data from the literature. A recalculation of previous benchmarks shows that the model retains its predictive power, while the assumed amount of depleted oxygen approaches measured values. The updated UNIVERSE could be used to investigate the impact of different combinations of pulse structure parameters (e.g., dose per pulse, pulse frequency, number of pulses, etc.), thereby aiding the optimization of potential clinical application and the development of suitable accelerators.

Keyword(s): FLASH ; UNIVERSE ; electrons ; ionizing radiation ; modeling ; temporal pulse structure ; ultra-high dose rate

Note: #EA:E050#LA:E210#

---

Contributing Institute(s):

1. E050 KKE Strahlentherapie (E050)
2. E210 Translationale Radioonkologie (E210)
3. DKTK HD zentral (HD01)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2022

---

Database coverage:
; ; ; Article Processing Charges ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---