TY  - JOUR
AU  - Clasen, Joanna L
AU  - Heath, Alicia K
AU  - Van Puyvelde, Heleen
AU  - Huybrechts, Inge
AU  - Park, Jin Young
AU  - Ferrari, Pietro
AU  - Scelo, Ghislaine
AU  - Ulvik, Arve
AU  - Midttun, Øivind
AU  - Ueland, Per Magne
AU  - Overvad, Kim
AU  - Eriksen, Anne Kirstine
AU  - Tjønneland, Anne
AU  - Kaaks, Rudolf
AU  - Katzke, Verena
AU  - Schulze, Matthias B
AU  - Palli, Domenico
AU  - Agnoli, Claudia
AU  - Chiodini, Paolo
AU  - Tumino, Rosario
AU  - Sacerdote, Carlotta
AU  - Zamora-Ros, Raul
AU  - Rodriguez-Barranco, Miguel
AU  - Santiuste, Carmen
AU  - Ardanaz, Eva
AU  - Amiano, Pilar
AU  - Schmidt, Julie A
AU  - Weiderpass, Elisabete
AU  - Gunter, Marc
AU  - Riboli, Elio
AU  - Cross, Amanda J
AU  - Johansson, Mattias
AU  - Muller, David C
TI  - Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
JO  - International journal of cancer
VL  - 151
IS  - 5
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2022-00626
SP  - 708-716
PY  - 2022
N1  - 2022 Sep 1;151(5):708-716
AB  - Previous studies have suggested that components of one-carbon metabolism, particularly circulating vitamin B6, have an etiological role in renal cell carcinoma (RCC). Vitamin B6 is a cofactor in the transsulfuration pathway. We sought to holistically investigate the role of the transsulfuration pathway in RCC risk. We conducted a nested case-control study (455 RCC cases and 455 matched controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Plasma samples from the baseline visit were analyzed for metabolites of the transsulfuration pathway, including pyridoxal 5'-phosphate (PLP, the biologically active form of vitamin B6), homocysteine, serine, cystathionine, and cysteine, in addition to folate. Bayesian conditional logistic regression was used to estimate associations of metabolites with RCC risk as well as interactions with established RCC risk factors. Circulating PLP and cysteine were inversely associated with RCC risk, and these association were not attenuated after adjustment for other transsulfuration metabolites (odds ratio (OR) and 90
KW  - dietary biomarkers (Other)
KW  - kidney cancer (Other)
KW  - transsulfuration (Other)
KW  - vitamin B6 (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35366005
DO  - DOI:10.1002/ijc.34009
UR  - https://inrepo02.dkfz.de/record/179375
ER  -