Journal Article

DKFZ-2022-00626

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Clasen, J. L. ; Heath, A. K. ; Van Puyvelde, H. ; Huybrechts, I. ; Park, J. Y. ; Ferrari, P. ; Scelo, G. ; Ulvik, A. ; Midttun, Ø. ; Ueland, P. M. ; Overvad, K. ; Eriksen, A. K. ; Tjønneland, A. ; Kaaks, R.DKFZ* ; Katzke, V.DKFZ* ; Schulze, M. B. ; Palli, D. ; Agnoli, C. ; Chiodini, P. ; Tumino, R. ; Sacerdote, C. ; Zamora-Ros, R. ; Rodriguez-Barranco, M. ; Santiuste, C. ; Ardanaz, E. ; Amiano, P. ; Schmidt, J. A. ; Weiderpass, E. ; Gunter, M. ; Riboli, E. ; Cross, A. J. ; Johansson, M. ; Muller, D. C.

2022
Wiley-Liss Bognor Regis

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Please use a persistent id in citations: doi:10.1002/ijc.34009

Abstract: Previous studies have suggested that components of one-carbon metabolism, particularly circulating vitamin B6, have an etiological role in renal cell carcinoma (RCC). Vitamin B6 is a cofactor in the transsulfuration pathway. We sought to holistically investigate the role of the transsulfuration pathway in RCC risk. We conducted a nested case-control study (455 RCC cases and 455 matched controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Plasma samples from the baseline visit were analyzed for metabolites of the transsulfuration pathway, including pyridoxal 5'-phosphate (PLP, the biologically active form of vitamin B6), homocysteine, serine, cystathionine, and cysteine, in addition to folate. Bayesian conditional logistic regression was used to estimate associations of metabolites with RCC risk as well as interactions with established RCC risk factors. Circulating PLP and cysteine were inversely associated with RCC risk, and these association were not attenuated after adjustment for other transsulfuration metabolites (odds ratio (OR) and 90% credible interval (CrI) per 1 SD increase in log concentration: 0.76 [0.66, 0.87]; 0.81 [0.66, 0.96], respectively). A comparison of joint metabolite profiles suggested substantially greater RCC risk for the profile representative of low overall transsulfuration function compared with high function (OR 2.70 [90% CrI 1.26, 5.70]). We found some statistical evidence of interactions of cysteine with body mass index, and PLP and homocysteine with smoking status, on their associations with RCC risk. In conclusion, we found evidence suggesting that the transsulfuration pathway may play a role in metabolic dysregulation leading to RCC development. This article is protected by copyright. All rights reserved.

Keyword(s): dietary biomarkers ; kidney cancer ; transsulfuration ; vitamin B6

Note: 2022 Sep 1;151(5):708-716

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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