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@ARTICLE{Clasen:179375,
      author       = {J. L. Clasen and A. K. Heath and H. Van Puyvelde and I.
                      Huybrechts and J. Y. Park and P. Ferrari and G. Scelo and A.
                      Ulvik and Ø. Midttun and P. M. Ueland and K. Overvad and A.
                      K. Eriksen and A. Tjønneland and R. Kaaks$^*$ and V.
                      Katzke$^*$ and M. B. Schulze and D. Palli and C. Agnoli and
                      P. Chiodini and R. Tumino and C. Sacerdote and R. Zamora-Ros
                      and M. Rodriguez-Barranco and C. Santiuste and E. Ardanaz
                      and P. Amiano and J. A. Schmidt and E. Weiderpass and M.
                      Gunter and E. Riboli and A. J. Cross and M. Johansson and D.
                      C. Muller},
      title        = {{B}iomarkers of the transsulfuration pathway and risk of
                      renal cell carcinoma in the {E}uropean {P}rospective
                      {I}nvestigation into {C}ancer and {N}utrition ({EPIC})
                      study.},
      journal      = {International journal of cancer},
      volume       = {151},
      number       = {5},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2022-00626},
      pages        = {708-716},
      year         = {2022},
      note         = {2022 Sep 1;151(5):708-716},
      abstract     = {Previous studies have suggested that components of
                      one-carbon metabolism, particularly circulating vitamin B6,
                      have an etiological role in renal cell carcinoma (RCC).
                      Vitamin B6 is a cofactor in the transsulfuration pathway. We
                      sought to holistically investigate the role of the
                      transsulfuration pathway in RCC risk. We conducted a nested
                      case-control study (455 RCC cases and 455 matched controls)
                      within the European Prospective Investigation into Cancer
                      and Nutrition (EPIC) study. Plasma samples from the baseline
                      visit were analyzed for metabolites of the transsulfuration
                      pathway, including pyridoxal 5'-phosphate (PLP, the
                      biologically active form of vitamin B6), homocysteine,
                      serine, cystathionine, and cysteine, in addition to folate.
                      Bayesian conditional logistic regression was used to
                      estimate associations of metabolites with RCC risk as well
                      as interactions with established RCC risk factors.
                      Circulating PLP and cysteine were inversely associated with
                      RCC risk, and these association were not attenuated after
                      adjustment for other transsulfuration metabolites (odds
                      ratio (OR) and $90\%$ credible interval (CrI) per 1 SD
                      increase in log concentration: 0.76 [0.66, 0.87]; 0.81
                      [0.66, 0.96], respectively). A comparison of joint
                      metabolite profiles suggested substantially greater RCC risk
                      for the profile representative of low overall
                      transsulfuration function compared with high function (OR
                      2.70 $[90\%$ CrI 1.26, 5.70]). We found some statistical
                      evidence of interactions of cysteine with body mass index,
                      and PLP and homocysteine with smoking status, on their
                      associations with RCC risk. In conclusion, we found evidence
                      suggesting that the transsulfuration pathway may play a role
                      in metabolic dysregulation leading to RCC development. This
                      article is protected by copyright. All rights reserved.},
      keywords     = {dietary biomarkers (Other) / kidney cancer (Other) /
                      transsulfuration (Other) / vitamin B6 (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35366005},
      doi          = {10.1002/ijc.34009},
      url          = {https://inrepo02.dkfz.de/record/179375},
}