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| 001 | 179436 | ||
| 005 | 20240229145544.0 | ||
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| 037 | _ | _ | |a DKFZ-2022-00676 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Harbs, Justin |b 0 |
| 245 | _ | _ | |a Circulating Sex Hormone Levels and Colon Cancer Risk in Men: A Nested Case-Control Study and Meta-Analysis. |
| 260 | _ | _ | |a Philadelphia, Pa. |c 2022 |b AACR |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1649333535_32468 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Endogenous sex hormones may contribute to higher colorectal cancer incidence rates in men compared with women, but despite an increased number of studies, clear evidence is lacking.We conducted a comprehensive nested case-control study of circulating concentrations of sex hormones, sex hormone precursors, and sex hormone binding globulin (SHBG) in relation to subsequent colon cancer risk in European men. Concentrations were measured using liquid LC/MS-MS in prospectively collected plasma samples from 690 cases and 690 matched controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Multivariable conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). In addition, we conducted a meta-analysis of previous studies on men.Circulating levels of testosterone (OR, 0.68; 95% CI, 0.51-0.89) and SHBG (OR, 0.77; 95% CI, 0.62-0.96) were inversely associated with colon cancer risk. For free testosterone, there was a nonsignificant inverse association (OR, 0.83; 95% CI, 0.58-1.18). In a dose-response meta-analysis of endogenous sex hormone levels, inverse associations with colorectal/colon cancer risk were found for testosterone [relative risks (RR) per 100 ng/dL = 0.98; 95% CI, 0.96-1.00; I2 = 22%] and free testosterone (RR per 1 ng/dL = 0.98; 95% CI, 0.95-1.00; I2 = 0%).Our results provide suggestive evidence for the association between testosterone, SHBG, and male colon cancer development.Additional support for the involvement of sex hormones in male colon cancer. |
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| 650 | _ | 7 | |a Gonadal Steroid Hormones |2 NLM Chemicals |
| 650 | _ | 7 | |a Sex Hormone-Binding Globulin |2 NLM Chemicals |
| 650 | _ | 7 | |a Testosterone |0 3XMK78S47O |2 NLM Chemicals |
| 650 | _ | 7 | |a Estradiol |0 4TI98Z838E |2 NLM Chemicals |
| 650 | _ | 2 | |a Case-Control Studies |2 MeSH |
| 650 | _ | 2 | |a Colonic Neoplasms: epidemiology |2 MeSH |
| 650 | _ | 2 | |a Estradiol |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Gonadal Steroid Hormones |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Logistic Models |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Prospective Studies |2 MeSH |
| 650 | _ | 2 | |a Risk Factors |2 MeSH |
| 650 | _ | 2 | |a Sex Hormone-Binding Globulin: metabolism |2 MeSH |
| 650 | _ | 2 | |a Testosterone |2 MeSH |
| 700 | 1 | _ | |a Rinaldi, Sabina |b 1 |
| 700 | 1 | _ | |a Gicquiau, Audrey |b 2 |
| 700 | 1 | _ | |a Keski-Rahkonen, Pekka |b 3 |
| 700 | 1 | _ | |a Mori, Nagisa |b 4 |
| 700 | 1 | _ | |a Liu, Xijia |b 5 |
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| 700 | 1 | _ | |a Schulze, Matthias B |0 0000-0002-0830-5277 |b 8 |
| 700 | 1 | _ | |a Agnoli, Claudia |0 0000-0003-4472-1179 |b 9 |
| 700 | 1 | _ | |a Tumino, Rosario |0 0000-0003-2666-414X |b 10 |
| 700 | 1 | _ | |a Bueno-de-Mesquita, Bas |b 11 |
| 700 | 1 | _ | |a Crous-Bou, Marta |b 12 |
| 700 | 1 | _ | |a Sánchez, Maria-Jose |0 0000-0003-4817-0757 |b 13 |
| 700 | 1 | _ | |a Aizpurua, Amaia |b 14 |
| 700 | 1 | _ | |a Chirlaque, María-Dolores |b 15 |
| 700 | 1 | _ | |a Gurrea, Aurelio Barricarte |b 16 |
| 700 | 1 | _ | |a Travis, Ruth C |0 0000-0002-9571-0763 |b 17 |
| 700 | 1 | _ | |a Watts, Eleanor L |0 0000-0001-9229-2589 |b 18 |
| 700 | 1 | _ | |a Christakoudi, Sofia |b 19 |
| 700 | 1 | _ | |a Tsilidis, Konstantinos K |0 0000-0002-8452-8472 |b 20 |
| 700 | 1 | _ | |a Weiderpass, Elisabete |0 0000-0003-2237-0128 |b 21 |
| 700 | 1 | _ | |a Gunter, Marc J |0 0000-0001-5472-6761 |b 22 |
| 700 | 1 | _ | |a Van Guelpen, Bethany |0 0000-0002-9692-101X |b 23 |
| 700 | 1 | _ | |a Murphy, Neil |b 24 |
| 700 | 1 | _ | |a Harlid, Sophia |0 0000-0001-8540-6891 |b 25 |
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