Journal Article

DKFZ-2022-00676

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Circulating Sex Hormone Levels and Colon Cancer Risk in Men: A Nested Case-Control Study and Meta-Analysis.

Harbs, J. ; Rinaldi, S. ; Gicquiau, A. ; Keski-Rahkonen, P. ; Mori, N. ; Liu, X. ; Kaaks, R.DKFZ* ; Katzke, V.DKFZ* ; Schulze, M. B. ; Agnoli, C. ; Tumino, R. ; Bueno-de-Mesquita, B. ; Crous-Bou, M. ; Sánchez, M.-J. ; Aizpurua, A. ; Chirlaque, M.-D. ; Gurrea, A. B. ; Travis, R. C. ; Watts, E. L. ; Christakoudi, S. ; Tsilidis, K. K. ; Weiderpass, E. ; Gunter, M. J. ; Van Guelpen, B. ; Murphy, N. ; Harlid, S.

2022
AACR Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1158/1055-9965.EPI-21-0996

Abstract: Endogenous sex hormones may contribute to higher colorectal cancer incidence rates in men compared with women, but despite an increased number of studies, clear evidence is lacking.We conducted a comprehensive nested case-control study of circulating concentrations of sex hormones, sex hormone precursors, and sex hormone binding globulin (SHBG) in relation to subsequent colon cancer risk in European men. Concentrations were measured using liquid LC/MS-MS in prospectively collected plasma samples from 690 cases and 690 matched controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Multivariable conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). In addition, we conducted a meta-analysis of previous studies on men.Circulating levels of testosterone (OR, 0.68; 95% CI, 0.51-0.89) and SHBG (OR, 0.77; 95% CI, 0.62-0.96) were inversely associated with colon cancer risk. For free testosterone, there was a nonsignificant inverse association (OR, 0.83; 95% CI, 0.58-1.18). In a dose-response meta-analysis of endogenous sex hormone levels, inverse associations with colorectal/colon cancer risk were found for testosterone [relative risks (RR) per 100 ng/dL = 0.98; 95% CI, 0.96-1.00; I2 = 22%] and free testosterone (RR per 1 ng/dL = 0.98; 95% CI, 0.95-1.00; I2 = 0%).Our results provide suggestive evidence for the association between testosterone, SHBG, and male colon cancer development.Additional support for the involvement of sex hormones in male colon cancer.

Keyword(s): Case-Control Studies (MeSH) ; Colonic Neoplasms: epidemiology (MeSH) ; Estradiol (MeSH) ; Female (MeSH) ; Gonadal Steroid Hormones (MeSH) ; Humans (MeSH) ; Logistic Models (MeSH) ; Male (MeSH) ; Prospective Studies (MeSH) ; Risk Factors (MeSH) ; Sex Hormone-Binding Globulin: metabolism (MeSH) ; Testosterone (MeSH) ; Gonadal Steroid Hormones ; Sex Hormone-Binding Globulin ; Testosterone ; Estradiol

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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