%0 Journal Article
%A Holowatyj, Andreana N
%A Ose, Jennifer
%A Gigic, Biljana
%A Lin, Tengda
%A Ulvik, Arve
%A Geijsen, Anne J M R
%A Brezina, Stefanie
%A Kiblawi, Rama
%A van Roekel, Eline H
%A Baierl, Andreas
%A Böhm, Jürgen
%A Bours, Martijn J L
%A Brenner, Hermann
%A Breukink, Stéphanie O
%A Chang-Claude, Jenny
%A de Wilt, Johannes H W
%A Grady, William M
%A Grünberger, Thomas
%A Gumpenberger, Tanja
%A Herpel, Esther
%A Hoffmeister, Michael
%A Keulen, Eric T P
%A Kok, Dieuwertje E
%A Koole, Janna L
%A Kosma, Katharina
%A Kouwenhoven, Ewout A
%A Kvalheim, Gry
%A Li, Christopher I
%A Schirmacher, Peter
%A Schrotz-King, Petra
%A Singer, Marie C
%A van Duijnhoven, Fränzel J B
%A van Halteren, Henk K
%A Vickers, Kathy
%A Vogelaar, F Jeroen
%A Warby, Christy A
%A Wesselink, Evertine
%A Ueland, Per M
%A Ulrich, Alexis B
%A Schneider, Martin
%A Habermann, Nina
%A Kampman, Ellen
%A Weijenberg, Matty P
%A Gsur, Andrea
%A Ulrich, Cornelia M
%T Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.
%J The American journal of clinical nutrition
%V 116
%N 2
%@ 0002-9165
%C Oxford
%I Oxford University Press
%M DKFZ-2022-01075
%P 303-313
%D 2022
%Z 2022 Aug 4;116(2):303-313
%X Folate-mediated one-carbon metabolism requires several nutrients, including vitamin B6. Circulating levels of biomarkers indicating high vitamin B6 status are associated with a reduced risk of colorectal cancer (CRC). However, little is known about the effect of B6 status in relation to clinical outcomes in CRC patients.We investigated survival outcomes in relation to vitamin B6 status in prospectively followed CRC patients.A total of 2031 patients with stage I-III CRC participated in six prospective patient cohorts in the international FOCUS Consortium. Preoperative blood samples were used to measure vitamin B6 status by the direct marker pyridoxal 5'-phosphate, PLP, as well as functional marker the HK-ratio (3'-hydroxykynurenine: [kynurenic acid + xanthurenic acid + 3'-hydroxy anthranilic acid + anthranilic acid]). Using Cox proportional hazards regression, we examined associations of vitamin B6 status with overall survival (OS), disease-free survival (DFS), and risk of recurrence, adjusted for patient age, sex, circulating creatinine levels, tumor site, stage, and cohort.After a median follow-up of 3.2 years for OS, higher preoperative vitamin B6 status as assessed by PLP and the functional marker HKr was associated with 16-32
%K HKr (Other)
%K PAR (Other)
%K PLP (Other)
%K cancer (Other)
%K colon cancer (Other)
%K colorectal cancer (Other)
%K mortality (Other)
%K one-carbon metabolism (Other)
%K rectal cancer (Other)
%K recurrence (Other)
%K survival (Other)
%K survivorship (Other)
%K vitamin b6 (Other)
%K vitamins (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35394006
%R 10.1093/ajcn/nqac090
%U https://inrepo02.dkfz.de/record/180076