Journal Article

DKFZ-2022-01075

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.

Holowatyj, A. N. ; Ose, J. ; Gigic, B. ; Lin, T. ; Ulvik, A. ; Geijsen, A. J. M. R. ; Brezina, S. ; Kiblawi, R. ; van Roekel, E. H. ; Baierl, A. ; Böhm, J. ; Bours, M. J. L. ; Brenner, H.DKFZ* ; Breukink, S. O. ; Chang-Claude, J.DKFZ* ; de Wilt, J. H. W. ; Grady, W. M. ; Grünberger, T. ; Gumpenberger, T. ; Herpel, E. ; Hoffmeister, M.DKFZ* ; Keulen, E. T. P. ; Kok, D. E. ; Koole, J. L. ; Kosma, K. ; Kouwenhoven, E. A. ; Kvalheim, G. ; Li, C. I. ; Schirmacher, P. ; Schrotz-King, P.DKFZ* ; Singer, M. C. ; van Duijnhoven, F. J. B. ; van Halteren, H. K. ; Vickers, K. ; Vogelaar, F. J. ; Warby, C. A. ; Wesselink, E. ; Ueland, P. M. ; Ulrich, A. B. ; Schneider, M. ; Habermann, N. ; Kampman, E. ; Weijenberg, M. P. ; Gsur, A. ; Ulrich, C. M.

2022
Oxford University Press Oxford

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Please use a persistent id in citations: doi:10.1093/ajcn/nqac090

Abstract: Folate-mediated one-carbon metabolism requires several nutrients, including vitamin B6. Circulating levels of biomarkers indicating high vitamin B6 status are associated with a reduced risk of colorectal cancer (CRC). However, little is known about the effect of B6 status in relation to clinical outcomes in CRC patients.We investigated survival outcomes in relation to vitamin B6 status in prospectively followed CRC patients.A total of 2031 patients with stage I-III CRC participated in six prospective patient cohorts in the international FOCUS Consortium. Preoperative blood samples were used to measure vitamin B6 status by the direct marker pyridoxal 5'-phosphate, PLP, as well as functional marker the HK-ratio (3'-hydroxykynurenine: [kynurenic acid + xanthurenic acid + 3'-hydroxy anthranilic acid + anthranilic acid]). Using Cox proportional hazards regression, we examined associations of vitamin B6 status with overall survival (OS), disease-free survival (DFS), and risk of recurrence, adjusted for patient age, sex, circulating creatinine levels, tumor site, stage, and cohort.After a median follow-up of 3.2 years for OS, higher preoperative vitamin B6 status as assessed by PLP and the functional marker HKr was associated with 16-32% higher all-cause and disease-free survival, although there was no significant association with disease recurrence (doubling in PLP concentration: hazard ratio, HROS, 0.68; 95% CI, 0.59,0.79; HRDFS, 0.84; 95% CI, 0.75,0.94; HRRecurrence, 0.96; 95% CI, 0.84,1.09; HKr: HROS, 2.04; 95% CI, 1.67,2.49; HRDFS, 1.56; 95% CI, 1.31,1.85; HRRecurrence, 1.21; 95% CI, 0.96,1.52). The association of PLP with improved OS was consistent across colorectal tumor site (right-sided colon: HROS, 0.75; 95% CI, 0.59,0.96; left-sided colon: HROS, 0.71; 95% CI, 0.55,0.92; rectosigmoid junction and rectum: HROS, 0.61; 95% CI, 0.47,0.78).Higher preoperative vitamin B6 status is associated with improved OS among stage I-III CRC patients.

Keyword(s): HKr ; PAR ; PLP ; cancer ; colon cancer ; colorectal cancer ; mortality ; one-carbon metabolism ; rectal cancer ; recurrence ; survival ; survivorship ; vitamin b6 ; vitamins

Note: 2022 Aug 4;116(2):303-313

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. Präventive Onkologie (C120)
3. DKTK HD zentral (HD01)
4. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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