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000180076 0247_ $$2doi$$a10.1093/ajcn/nqac090
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000180076 0247_ $$2ISSN$$a0002-9165
000180076 0247_ $$2ISSN$$a0095-9871
000180076 0247_ $$2ISSN$$a1938-3207
000180076 0247_ $$2ISSN$$a1938-3215
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000180076 037__ $$aDKFZ-2022-01075
000180076 041__ $$aEnglish
000180076 082__ $$a570
000180076 1001_ $$aHolowatyj, Andreana N$$b0
000180076 245__ $$aHigher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.
000180076 260__ $$aOxford$$bOxford University Press$$c2022
000180076 3367_ $$2DRIVER$$aarticle
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000180076 500__ $$a2022 Aug 4;116(2):303-313
000180076 520__ $$aFolate-mediated one-carbon metabolism requires several nutrients, including vitamin B6. Circulating levels of biomarkers indicating high vitamin B6 status are associated with a reduced risk of colorectal cancer (CRC). However, little is known about the effect of B6 status in relation to clinical outcomes in CRC patients.We investigated survival outcomes in relation to vitamin B6 status in prospectively followed CRC patients.A total of 2031 patients with stage I-III CRC participated in six prospective patient cohorts in the international FOCUS Consortium. Preoperative blood samples were used to measure vitamin B6 status by the direct marker pyridoxal 5'-phosphate, PLP, as well as functional marker the HK-ratio (3'-hydroxykynurenine: [kynurenic acid + xanthurenic acid + 3'-hydroxy anthranilic acid + anthranilic acid]). Using Cox proportional hazards regression, we examined associations of vitamin B6 status with overall survival (OS), disease-free survival (DFS), and risk of recurrence, adjusted for patient age, sex, circulating creatinine levels, tumor site, stage, and cohort.After a median follow-up of 3.2 years for OS, higher preoperative vitamin B6 status as assessed by PLP and the functional marker HKr was associated with 16-32% higher all-cause and disease-free survival, although there was no significant association with disease recurrence (doubling in PLP concentration: hazard ratio, HROS, 0.68; 95% CI, 0.59,0.79; HRDFS, 0.84; 95% CI, 0.75,0.94; HRRecurrence, 0.96; 95% CI, 0.84,1.09; HKr: HROS, 2.04; 95% CI, 1.67,2.49; HRDFS, 1.56; 95% CI, 1.31,1.85; HRRecurrence, 1.21; 95% CI, 0.96,1.52). The association of PLP with improved OS was consistent across colorectal tumor site (right-sided colon: HROS, 0.75; 95% CI, 0.59,0.96; left-sided colon: HROS, 0.71; 95% CI, 0.55,0.92; rectosigmoid junction and rectum: HROS, 0.61; 95% CI, 0.47,0.78).Higher preoperative vitamin B6 status is associated with improved OS among stage I-III CRC patients.
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000180076 650_7 $$2Other$$aHKr
000180076 650_7 $$2Other$$aPAR
000180076 650_7 $$2Other$$aPLP
000180076 650_7 $$2Other$$acancer
000180076 650_7 $$2Other$$acolon cancer
000180076 650_7 $$2Other$$acolorectal cancer
000180076 650_7 $$2Other$$amortality
000180076 650_7 $$2Other$$aone-carbon metabolism
000180076 650_7 $$2Other$$arectal cancer
000180076 650_7 $$2Other$$arecurrence
000180076 650_7 $$2Other$$asurvival
000180076 650_7 $$2Other$$asurvivorship
000180076 650_7 $$2Other$$avitamin b6
000180076 650_7 $$2Other$$avitamins
000180076 7001_ $$aOse, Jennifer$$b1
000180076 7001_ $$aGigic, Biljana$$b2
000180076 7001_ $$aLin, Tengda$$b3
000180076 7001_ $$aUlvik, Arve$$b4
000180076 7001_ $$aGeijsen, Anne J M R$$b5
000180076 7001_ $$aBrezina, Stefanie$$b6
000180076 7001_ $$aKiblawi, Rama$$b7
000180076 7001_ $$avan Roekel, Eline H$$b8
000180076 7001_ $$aBaierl, Andreas$$b9
000180076 7001_ $$aBöhm, Jürgen$$b10
000180076 7001_ $$aBours, Martijn J L$$b11
000180076 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b12$$udkfz
000180076 7001_ $$aBreukink, Stéphanie O$$b13
000180076 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b14$$udkfz
000180076 7001_ $$ade Wilt, Johannes H W$$b15
000180076 7001_ $$aGrady, William M$$b16
000180076 7001_ $$aGrünberger, Thomas$$b17
000180076 7001_ $$aGumpenberger, Tanja$$b18
000180076 7001_ $$aHerpel, Esther$$b19
000180076 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b20$$udkfz
000180076 7001_ $$aKeulen, Eric T P$$b21
000180076 7001_ $$aKok, Dieuwertje E$$b22
000180076 7001_ $$aKoole, Janna L$$b23
000180076 7001_ $$aKosma, Katharina$$b24
000180076 7001_ $$aKouwenhoven, Ewout A$$b25
000180076 7001_ $$aKvalheim, Gry$$b26
000180076 7001_ $$aLi, Christopher I$$b27
000180076 7001_ $$aSchirmacher, Peter$$b28
000180076 7001_ $$0P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86$$aSchrotz-King, Petra$$b29$$udkfz
000180076 7001_ $$aSinger, Marie C$$b30
000180076 7001_ $$avan Duijnhoven, Fränzel J B$$b31
000180076 7001_ $$avan Halteren, Henk K$$b32
000180076 7001_ $$aVickers, Kathy$$b33
000180076 7001_ $$aVogelaar, F Jeroen$$b34
000180076 7001_ $$aWarby, Christy A$$b35
000180076 7001_ $$aWesselink, Evertine$$b36
000180076 7001_ $$aUeland, Per M$$b37
000180076 7001_ $$aUlrich, Alexis B$$b38
000180076 7001_ $$aSchneider, Martin$$b39
000180076 7001_ $$aHabermann, Nina$$b40
000180076 7001_ $$aKampman, Ellen$$b41
000180076 7001_ $$aWeijenberg, Matty P$$b42
000180076 7001_ $$aGsur, Andrea$$b43
000180076 7001_ $$aUlrich, Cornelia M$$b44
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