TY  - JOUR
AU  - Holowatyj, Andreana N
AU  - Ose, Jennifer
AU  - Gigic, Biljana
AU  - Lin, Tengda
AU  - Ulvik, Arve
AU  - Geijsen, Anne J M R
AU  - Brezina, Stefanie
AU  - Kiblawi, Rama
AU  - van Roekel, Eline H
AU  - Baierl, Andreas
AU  - Böhm, Jürgen
AU  - Bours, Martijn J L
AU  - Brenner, Hermann
AU  - Breukink, Stéphanie O
AU  - Chang-Claude, Jenny
AU  - de Wilt, Johannes H W
AU  - Grady, William M
AU  - Grünberger, Thomas
AU  - Gumpenberger, Tanja
AU  - Herpel, Esther
AU  - Hoffmeister, Michael
AU  - Keulen, Eric T P
AU  - Kok, Dieuwertje E
AU  - Koole, Janna L
AU  - Kosma, Katharina
AU  - Kouwenhoven, Ewout A
AU  - Kvalheim, Gry
AU  - Li, Christopher I
AU  - Schirmacher, Peter
AU  - Schrotz-King, Petra
AU  - Singer, Marie C
AU  - van Duijnhoven, Fränzel J B
AU  - van Halteren, Henk K
AU  - Vickers, Kathy
AU  - Vogelaar, F Jeroen
AU  - Warby, Christy A
AU  - Wesselink, Evertine
AU  - Ueland, Per M
AU  - Ulrich, Alexis B
AU  - Schneider, Martin
AU  - Habermann, Nina
AU  - Kampman, Ellen
AU  - Weijenberg, Matty P
AU  - Gsur, Andrea
AU  - Ulrich, Cornelia M
TI  - Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.
JO  - The American journal of clinical nutrition
VL  - 116
IS  - 2
SN  - 0002-9165
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2022-01075
SP  - 303-313
PY  - 2022
N1  - 2022 Aug 4;116(2):303-313
AB  - Folate-mediated one-carbon metabolism requires several nutrients, including vitamin B6. Circulating levels of biomarkers indicating high vitamin B6 status are associated with a reduced risk of colorectal cancer (CRC). However, little is known about the effect of B6 status in relation to clinical outcomes in CRC patients.We investigated survival outcomes in relation to vitamin B6 status in prospectively followed CRC patients.A total of 2031 patients with stage I-III CRC participated in six prospective patient cohorts in the international FOCUS Consortium. Preoperative blood samples were used to measure vitamin B6 status by the direct marker pyridoxal 5'-phosphate, PLP, as well as functional marker the HK-ratio (3'-hydroxykynurenine: [kynurenic acid + xanthurenic acid + 3'-hydroxy anthranilic acid + anthranilic acid]). Using Cox proportional hazards regression, we examined associations of vitamin B6 status with overall survival (OS), disease-free survival (DFS), and risk of recurrence, adjusted for patient age, sex, circulating creatinine levels, tumor site, stage, and cohort.After a median follow-up of 3.2 years for OS, higher preoperative vitamin B6 status as assessed by PLP and the functional marker HKr was associated with 16-32
KW  - HKr (Other)
KW  - PAR (Other)
KW  - PLP (Other)
KW  - cancer (Other)
KW  - colon cancer (Other)
KW  - colorectal cancer (Other)
KW  - mortality (Other)
KW  - one-carbon metabolism (Other)
KW  - rectal cancer (Other)
KW  - recurrence (Other)
KW  - survival (Other)
KW  - survivorship (Other)
KW  - vitamin b6 (Other)
KW  - vitamins (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35394006
DO  - DOI:10.1093/ajcn/nqac090
UR  - https://inrepo02.dkfz.de/record/180076
ER  -