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@ARTICLE{Ose:180230,
      author       = {J. Ose and B. Gigic and S. Hardikar and T. Lin and C.
                      Himbert and C. A. Warby and A. R. Peoples and C. L. Lindley
                      and J. Boehm and P. Schrotz-King$^*$ and J. C. Figueiredo
                      and A. T. Toriola and E. M. Siegel and C. I. Li and A.
                      Ulrich and M. Schneider and D. Shibata and C. M. Ulrich},
      title        = {{P}re-surgery adhesion molecules and angiogenesis
                      biomarkers are differently associated with outcomes in colon
                      and rectal cancer: {R}esults from the {C}olo{C}are {S}tudy.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {31},
      number       = {8},
      issn         = {1055-9965},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2022-01181},
      pages        = {1650-1660},
      year         = {2022},
      note         = {2022 Aug 2;31(8):1650-1660},
      abstract     = {Cell-to-cell adhesion and angiogenesis are hallmarks of
                      cancer. No studies have examined associations of
                      adhesion-molecules and angiogenesis biomarkers with clinical
                      outcomes in colorectal cancer (CRC).In pre-surgery serum
                      from n=426 CRC patients (stage I-III) we investigated
                      associations of CRP, SAA, adhesion molecules (sICAM-1,
                      sVCAM-1), and angiogenesis markers (VEGF-A, and -D) with
                      overall survival (OS), disease-free survival (DFS), and risk
                      of recurrence. We computed hazard ratios (HR) and $95\%$
                      confidence intervals; adjusted for age, sex, BMI, stage,
                      site, and study site, stratified by tumor site in
                      exploratory analyses.N=65 $(15\%)$ were deceased, 59
                      patients $(14\%)$ had a recurrence after a median follow-up
                      of 31 months. We observed significant associations of
                      biomarkers with OS, DFS, and risk of recurrence on a
                      continuous scale and comparing top to bottom tertile, with
                      HRs ranging between 1.19 - 13.92. CRP was associated with
                      risk of death and recurrence in patients in the top tertile
                      compared to patients in the bottom tertile, e.g., risk of
                      recurrence HRQ3-Q1:13.92 (1.72, 112.56). Significant
                      heterogeneity between biomarkers and clinical outcomes was
                      observed in stratified analysis by tumor site for CRP, SAA,
                      sICAM-1, sVCAM-1, and VEGF-D. VEGF-D was associated with a
                      3-fold increase in risk of death for rectal cancer (HRlog2:
                      3.26; $95\%$ CI: 1.58-6.70) compared to no association for
                      colon cancer (HRlog2: 0.78; $95\%$ CI: 0.35-1.73;
                      pheterogenity =0.01).Adhesion molecules and angiogenesis
                      biomarkers are independent prognostic markers for CRC, with
                      differences by tumor site.There is need for tailored
                      treatment for colon and rectal cancer.},
      cin          = {C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35667092},
      doi          = {10.1158/1055-9965.EPI-22-0092},
      url          = {https://inrepo02.dkfz.de/record/180230},
}