Journal Article

DKFZ-2022-01181

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Pre-surgery adhesion molecules and angiogenesis biomarkers are differently associated with outcomes in colon and rectal cancer: Results from the ColoCare Study.

Ose, J. ; Gigic, B. ; Hardikar, S. ; Lin, T. ; Himbert, C. ; Warby, C. A. ; Peoples, A. R. ; Lindley, C. L. ; Boehm, J. ; Schrotz-King, P.DKFZ* ; Figueiredo, J. C. ; Toriola, A. T. ; Siegel, E. M. ; Li, C. I. ; Ulrich, A. ; Schneider, M. ; Shibata, D. ; Ulrich, C. M.

2022
AACR Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1158/1055-9965.EPI-22-0092  doi:DOI: 10.1158/1055-9965.EPI-22-0092

Abstract: Cell-to-cell adhesion and angiogenesis are hallmarks of cancer. No studies have examined associations of adhesion-molecules and angiogenesis biomarkers with clinical outcomes in colorectal cancer (CRC).In pre-surgery serum from n=426 CRC patients (stage I-III) we investigated associations of CRP, SAA, adhesion molecules (sICAM-1, sVCAM-1), and angiogenesis markers (VEGF-A, and -D) with overall survival (OS), disease-free survival (DFS), and risk of recurrence. We computed hazard ratios (HR) and 95% confidence intervals; adjusted for age, sex, BMI, stage, site, and study site, stratified by tumor site in exploratory analyses.N=65 (15%) were deceased, 59 patients (14%) had a recurrence after a median follow-up of 31 months. We observed significant associations of biomarkers with OS, DFS, and risk of recurrence on a continuous scale and comparing top to bottom tertile, with HRs ranging between 1.19 - 13.92. CRP was associated with risk of death and recurrence in patients in the top tertile compared to patients in the bottom tertile, e.g., risk of recurrence HRQ3-Q1:13.92 (1.72, 112.56). Significant heterogeneity between biomarkers and clinical outcomes was observed in stratified analysis by tumor site for CRP, SAA, sICAM-1, sVCAM-1, and VEGF-D. VEGF-D was associated with a 3-fold increase in risk of death for rectal cancer (HRlog2: 3.26; 95% CI: 1.58-6.70) compared to no association for colon cancer (HRlog2: 0.78; 95% CI: 0.35-1.73; pheterogenity =0.01).Adhesion molecules and angiogenesis biomarkers are independent prognostic markers for CRC, with differences by tumor site.There is need for tailored treatment for colon and rectal cancer.

Note: 2022 Aug 2;31(8):1650-1660

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Contributing Institute(s):

1. Präventive Onkologie (C120)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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