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000180467 1001_ $$aFresnais, Margaux$$b0
000180467 245__ $$aAnalytical Performance Evaluation of New DESI Enhancements for Targeted Drug Quantification in Tissue Sections.
000180467 260__ $$aBasel$$bMDPI$$c2022
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000180467 520__ $$aDesorption/ionization (DI)-mass spectrometric (MS) methods offer considerable advantages of rapidity and low-sample input for the analysis of solid biological matrices such as tissue sections. The concept of desorption electrospray ionization (DESI) offers the possibility to ionize compounds from solid surfaces at atmospheric pressure, without the addition of organic compounds to initiate desorption. However, severe drawbacks from former DESI hardware stability made the development of assays for drug quantification difficult. In the present study, the potential of new prototype source setups (High Performance DESI Sprayer and Heated Transfer Line) for the development of drug quantification assays in tissue sections was evaluated. It was demonstrated that following dedicated optimization, new DESI XS enhancements present promising options regarding targeted quantitative analyses. As a model compound for these developments, ulixertinib, an inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2 was used.
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000180467 650_7 $$2Other$$adesorption electrospray ionization
000180467 650_7 $$2Other$$adrug
000180467 650_7 $$2Other$$amass spectrometry
000180467 650_7 $$2Other$$aprofiling
000180467 650_7 $$2Other$$aquantification
000180467 7001_ $$aLiang, Siwen$$b1
000180467 7001_ $$aBreitkopf, Marius$$b2
000180467 7001_ $$aLindner, Joshua Raoul$$b3
000180467 7001_ $$00000-0001-5798-2242$$aClaude, Emmanuelle$$b4
000180467 7001_ $$aPringle, Steven$$b5
000180467 7001_ $$aLevkin, Pavel A$$b6
000180467 7001_ $$aDemir, Konstantin$$b7
000180467 7001_ $$0P:(DE-He78)2b12a7cfc604eb9816670e995f7af508$$aBenzel, Julia$$b8$$udkfz
000180467 7001_ $$0P:(DE-He78)303cfc65bbd4cdc79617186d2267d9fd$$aSundheimer, Julia$$b9$$udkfz
000180467 7001_ $$0P:(DE-He78)5f5223d7faa01a1e1df8a30d85cff5b0$$aStatz, Britta$$b10$$udkfz
000180467 7001_ $$0P:(DE-He78)a7c1bbac024fa232d9c6b78443328d9d$$aPajtler, Kristian$$b11$$udkfz
000180467 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b12$$udkfz
000180467 7001_ $$aHaefeli, Walter E$$b13
000180467 7001_ $$00000-0002-2190-1698$$aBurhenne, Jürgen$$b14
000180467 7001_ $$00000-0003-2003-1886$$aLonguespée, Rémi$$b15
000180467 773__ $$0PERI:(DE-600)2193542-7$$a10.3390/ph15060694$$gVol. 15, no. 6, p. 694 -$$n6$$p694$$tPharmaceuticals$$v15$$x1424-8247$$y2022
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