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@ARTICLE{Fresnais:180467,
      author       = {M. Fresnais and S. Liang and M. Breitkopf and J. R. Lindner
                      and E. Claude and S. Pringle and P. A. Levkin and K. Demir
                      and J. Benzel$^*$ and J. Sundheimer$^*$ and B. Statz$^*$ and
                      K. Pajtler$^*$ and S. Pfister$^*$ and W. E. Haefeli and J.
                      Burhenne and R. Longuespée},
      title        = {{A}nalytical {P}erformance {E}valuation of {N}ew {DESI}
                      {E}nhancements for {T}argeted {D}rug {Q}uantification in
                      {T}issue {S}ections.},
      journal      = {Pharmaceuticals},
      volume       = {15},
      number       = {6},
      issn         = {1424-8247},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2022-01346},
      pages        = {694},
      year         = {2022},
      abstract     = {Desorption/ionization (DI)-mass spectrometric (MS) methods
                      offer considerable advantages of rapidity and low-sample
                      input for the analysis of solid biological matrices such as
                      tissue sections. The concept of desorption electrospray
                      ionization (DESI) offers the possibility to ionize compounds
                      from solid surfaces at atmospheric pressure, without the
                      addition of organic compounds to initiate desorption.
                      However, severe drawbacks from former DESI hardware
                      stability made the development of assays for drug
                      quantification difficult. In the present study, the
                      potential of new prototype source setups (High Performance
                      DESI Sprayer and Heated Transfer Line) for the development
                      of drug quantification assays in tissue sections was
                      evaluated. It was demonstrated that following dedicated
                      optimization, new DESI XS enhancements present promising
                      options regarding targeted quantitative analyses. As a model
                      compound for these developments, ulixertinib, an inhibitor
                      of extracellular signal-regulated kinase (ERK) 1 and 2 was
                      used.},
      keywords     = {desorption electrospray ionization (Other) / drug (Other) /
                      mass spectrometry (Other) / profiling (Other) /
                      quantification (Other)},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35745613},
      doi          = {10.3390/ph15060694},
      url          = {https://inrepo02.dkfz.de/record/180467},
}