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@ARTICLE{Heath:180671,
      author       = {A. K. Heath and D. C. Muller and P. A. van den Brandt and
                      E. Critselis and M. Gunter and P. Vineis and E. Weiderpass
                      and H. Boeing and P. Ferrari and M. A. Merritt and A. L.
                      Rostgaard-Hansen and A. Tjønneland and K. Overvad and V.
                      Katzke$^*$ and B. Srour$^*$ and G. Masala and C. Sacerdote
                      and F. Ricceri and F. Pasanisi and B. Bueno-de-Mesquita and
                      G. S. Downward and G. Skeie and T. M. Sandanger and M.
                      Crous-Bou and M. Rodríguez-Barranco and P. Amiano and J. M.
                      Huerta and E. Ardanaz and I. Drake and M. Johansson and I.
                      Johansson and T. Key and N. Papadimitriou and E. Riboli and
                      I. Tzoulaki and K. K. Tsilidis},
      title        = {{D}iet-wide association study of 92 foods and nutrients and
                      lung cancer risk in the {E}uropean {P}rospective
                      {I}nvestigation into {C}ancer and {N}utrition study and the
                      {N}etherlands {C}ohort {S}tudy.},
      journal      = {International journal of cancer},
      volume       = {151},
      number       = {11},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2022-01471},
      pages        = {1935-1946},
      year         = {2022},
      note         = {2022 Dec 1;151(11):1935-1946},
      abstract     = {It is unclear whether diet, and in particular certain foods
                      or nutrients, are associated with lung cancer risk. We
                      assessed associations of 92 dietary factors with lung cancer
                      risk in 327,790 participants in the European Prospective
                      Investigation into Cancer and Nutrition (EPIC). Cox
                      regression yielded adjusted hazard ratios (HRs) and $95\%$
                      confidence intervals (CIs) per standard deviation (SD)
                      higher intake/day of each food/nutrient. Correction for
                      multiple comparisons was performed using the false discovery
                      rate and identified associations were evaluated in the
                      Netherlands Cohort Study (NLCS). In EPIC, 2,420 incident
                      lung cancer cases were identified during a median of 15
                      years of follow-up. Higher intakes of fibre (HR per 1 SD
                      higher intake/day=0.91, $95\%CI$ 0.87-0.96), fruit (HR=0.91,
                      $95\%CI$ 0.86-0.96), and vitamin C (HR=0.91, $95\%CI$
                      0.86-0.96) were associated with a lower risk of lung cancer,
                      whereas offal (HR=1.08, $95\%CI$ 1.03-1.14), retinol
                      (HR=1.06, $95\%CI$ 1.03-1.10), and beer/cider (HR=1.04,
                      $95\%CI$ 1.02-1.07) intakes were positively associated with
                      lung cancer risk. Associations did not differ by sex and
                      there was less evidence for associations among never
                      smokers. None of the six associations with overall lung
                      cancer risk identified in EPIC were replicated in the NLCS
                      (2,861 cases), however in analyses of histological subtypes,
                      inverse associations of fruit and vitamin C with squamous
                      cell carcinoma were replicated in the NLCS. Overall, there
                      is little evidence that intakes of specific foods and
                      nutrients play a major role in primary lung cancer risk, but
                      fruit and vitamin C intakes seem to be inversely associated
                      with squamous cell lung cancer. This article is protected by
                      copyright. All rights reserved.},
      keywords     = {cohort study (Other) / diet (Other) / foods (Other) / lung
                      cancer (Other) / nutrients (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35830197},
      doi          = {10.1002/ijc.34211},
      url          = {https://inrepo02.dkfz.de/record/180671},
}