Journal Article

DKFZ-2022-01471

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study.

Heath, A. K. ; Muller, D. C. ; van den Brandt, P. A. ; Critselis, E. ; Gunter, M. ; Vineis, P. ; Weiderpass, E. ; Boeing, H. ; Ferrari, P. ; Merritt, M. A. ; Rostgaard-Hansen, A. L. ; Tjønneland, A. ; Overvad, K. ; Katzke, V.DKFZ* ; Srour, B.DKFZ* ; Masala, G. ; Sacerdote, C. ; Ricceri, F. ; Pasanisi, F. ; Bueno-de-Mesquita, B. ; Downward, G. S. ; Skeie, G. ; Sandanger, T. M. ; Crous-Bou, M. ; Rodríguez-Barranco, M. ; Amiano, P. ; Huerta, J. M. ; Ardanaz, E. ; Drake, I. ; Johansson, M. ; Johansson, I. ; Key, T. ; Papadimitriou, N. ; Riboli, E. ; Tzoulaki, I. ; Tsilidis, K. K.

2022
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.34211

Abstract: It is unclear whether diet, and in particular certain foods or nutrients, are associated with lung cancer risk. We assessed associations of 92 dietary factors with lung cancer risk in 327,790 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per standard deviation (SD) higher intake/day of each food/nutrient. Correction for multiple comparisons was performed using the false discovery rate and identified associations were evaluated in the Netherlands Cohort Study (NLCS). In EPIC, 2,420 incident lung cancer cases were identified during a median of 15 years of follow-up. Higher intakes of fibre (HR per 1 SD higher intake/day=0.91, 95%CI 0.87-0.96), fruit (HR=0.91, 95%CI 0.86-0.96), and vitamin C (HR=0.91, 95%CI 0.86-0.96) were associated with a lower risk of lung cancer, whereas offal (HR=1.08, 95%CI 1.03-1.14), retinol (HR=1.06, 95%CI 1.03-1.10), and beer/cider (HR=1.04, 95%CI 1.02-1.07) intakes were positively associated with lung cancer risk. Associations did not differ by sex and there was less evidence for associations among never smokers. None of the six associations with overall lung cancer risk identified in EPIC were replicated in the NLCS (2,861 cases), however in analyses of histological subtypes, inverse associations of fruit and vitamin C with squamous cell carcinoma were replicated in the NLCS. Overall, there is little evidence that intakes of specific foods and nutrients play a major role in primary lung cancer risk, but fruit and vitamin C intakes seem to be inversely associated with squamous cell lung cancer. This article is protected by copyright. All rights reserved.

Keyword(s): cohort study ; diet ; foods ; lung cancer ; nutrients

Note: 2022 Dec 1;151(11):1935-1946

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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