Journal Article (Review Article)

DKFZ-2022-01490

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Advancement and Future Perspective of FAPI PET/CT In Gynecological Malignancies.

Dendl, K. ; Koerber, S. A.DKFZ* ; Tamburini, K. ; Mori, Y. ; Cardinale, J. ; Haberkorn, U.DKFZ* ; Giesel, F. L.

2022
Saunders Duluth, Minn.

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Please use a persistent id in citations: doi:10.1053/j.semnuclmed.2022.04.002

Abstract: Fibroblast activation protein (FAP) is ubiquitously present in healthy tissue, and additionally upregulated by cancer associated fibroblasts (CAFs) leading to high levels of FAP. Thus, neoplastic tissue, which is containing CAFs, characterized by a high presence of FAP. Moreover, in more than 90% of all epithelial tumors this phenomenon seems to occur, including many gynecological tumors, providing the foundation for a successful application of FAP-ligands. However, FAP upregulation, can also be initiated by benign conditions such as inflammation, hormonal-influence, and wound healing. Gynecological cancers seem to represent a field of interest for the utilization of FAPI-PET/CT to potentially improve staging, restaging and therapeutic management. First highly promising investigations demand further research in order to validate these preliminary findings.

Note: 2022 Sep;52(5):628-634

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Contributing Institute(s):

1. E050 KKE Strahlentherapie (E050)
2. E060 KKE Nuklearmedizin (E060)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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