Journal Article (Review Article)

DKFZ-2022-01556

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Site-Specific Considerations on Engineered T Cells for Malignant Gliomas.

Elmadany, N. (First author)DKFZ* ; Alhalabi, O.DKFZ* ; Platten, M.DKFZ* ; Bunse, L. (Last author)DKFZ*

2022
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/biomedicines10071738

Abstract: Immunotherapy has revolutionized cancer treatment. Despite the recent advances in immunotherapeutic approaches for several tumor entities, limited response has been observed in malignant gliomas, including glioblastoma (GBM). Conversely, one of the emerging immunotherapeutic modalities is chimeric antigen receptors (CAR) T cell therapy, which demonstrated promising clinical responses in other solid tumors. Current pre-clinical and interventional clinical studies suggest improved efficacy when CAR-T cells are delivered locoregionally, rather than intravenously. In this review, we summarize possible CAR-T cell administration routes including locoregional therapy, systemic administration with and without focused ultrasound, direct intra-arterial drug delivery and nanoparticle-enhanced delivery in glioma. Moreover, we discuss published as well as ongoing and planned clinical trials involving CAR-T cell therapy in malignant glioma. With increasing neoadjuvant and/or adjuvant combinatorial immunotherapeutic concepts and modalities with specific modes of action for malignant glioma, selection of administration routes becomes increasingly important.

Keyword(s): CAR T cells ; CARs ; FUS ; glioblastoma ; glioma ; intrathecal delivery ; nanotechnology ; systemic delivery

Note: #EA:D170#LA:D170# / HI-TRON

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Contributing Institute(s):

1. KKE Neuroimmunologie und Hirntumorimmunologie (D170)
2. DKTK HD zentral (HD01)
3. B067 Juniorgruppe Brain Tumor Translational Target (B067)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2022

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Database coverage:
; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Essential Science Indicators ; Fees ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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