%0 Journal Article
%A Prasuhn, Jannik
%A Göttlich, Martin
%A Großer, Sinja S
%A Reuther, Katharina
%A Ebeling, Britt
%A Bodemann, Christina
%A Hanssen, Henrike
%A Nagel, Armin
%A Brüggemann, Norbert
%T Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy.
%J Biomedicines
%V 10
%N 7
%@ 2227-9059
%C Basel
%I MDPI
%M DKFZ-2022-01566
%P 1728
%D 2022
%X Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (23Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) 23Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. 23Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.
%K 23Na-MRI (Other)
%K PSP (Other)
%K heteronuclear MRI (Other)
%K neurodegeneration (Other)
%K progressive supranuclear palsy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35885033
%R 10.3390/biomedicines10071728
%U https://inrepo02.dkfz.de/record/180804