Journal Article

DKFZ-2022-01566

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy.

Prasuhn, J. ; Göttlich, M. ; Großer, S. S. ; Reuther, K. ; Ebeling, B. ; Bodemann, C. ; Hanssen, H. ; Nagel, A.DKFZ* ; Brüggemann, N.

2022
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/biomedicines10071728

Abstract: Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (23Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) 23Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. 23Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.

Keyword(s): 23Na-MRI ; PSP ; heteronuclear MRI ; neurodegeneration ; progressive supranuclear palsy

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Contributing Institute(s):

1. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2022

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