TY  - JOUR
AU  - Prasuhn, Jannik
AU  - Göttlich, Martin
AU  - Großer, Sinja S
AU  - Reuther, Katharina
AU  - Ebeling, Britt
AU  - Bodemann, Christina
AU  - Hanssen, Henrike
AU  - Nagel, Armin
AU  - Brüggemann, Norbert
TI  - Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy.
JO  - Biomedicines
VL  - 10
IS  - 7
SN  - 2227-9059
CY  - Basel
PB  - MDPI
M1  - DKFZ-2022-01566
SP  - 1728
PY  - 2022
AB  - Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (23Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) 23Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. 23Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.
KW  - 23Na-MRI (Other)
KW  - PSP (Other)
KW  - heteronuclear MRI (Other)
KW  - neurodegeneration (Other)
KW  - progressive supranuclear palsy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35885033
DO  - DOI:10.3390/biomedicines10071728
UR  - https://inrepo02.dkfz.de/record/180804
ER  -