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@ARTICLE{Prasuhn:180804,
      author       = {J. Prasuhn and M. Göttlich and S. S. Großer and K.
                      Reuther and B. Ebeling and C. Bodemann and H. Hanssen and A.
                      Nagel$^*$ and N. Brüggemann},
      title        = {{I}ncreased {S}ubcortical {S}odium {L}evels in {P}atients
                      with {P}rogressive {S}upranuclear {P}alsy.},
      journal      = {Biomedicines},
      volume       = {10},
      number       = {7},
      issn         = {2227-9059},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2022-01566},
      pages        = {1728},
      year         = {2022},
      abstract     = {Progressive supranuclear palsy (PSP) is a debilitating
                      neurodegenerative disease characterized by an aggressive
                      disease course. Total and intracellular-weighted sodium
                      imaging (23Na-MRI) is a promising method for investigating
                      neurodegeneration in vivo. We enrolled 10 patients with PSP
                      and 20 age- and gender-matched healthy control subjects; all
                      study subjects underwent a neurological examination,
                      whole-brain structural, and (total and
                      intracellular-weighted) 23Na-MRI. Voxel-wise analyses
                      revealed increased brainstem total sodium content in PSP
                      that correlated with disease severity. The ROI-wise analysis
                      highlighted additional sodium level changes in other regions
                      implicated in the pathophysiology of PSP. 23Na-MRI yields
                      substantial benefits for the diagnostic workup of patients
                      with PSP and adds complementary information on the
                      underlying neurodegenerative tissue changes in PSP.},
      keywords     = {23Na-MRI (Other) / PSP (Other) / heteronuclear MRI (Other)
                      / neurodegeneration (Other) / progressive supranuclear palsy
                      (Other)},
      cin          = {E020},
      ddc          = {570},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35885033},
      doi          = {10.3390/biomedicines10071728},
      url          = {https://inrepo02.dkfz.de/record/180804},
}