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| 001 | 180804 | ||
| 005 | 20240229145633.0 | ||
| 024 | 7 | _ | |a 10.3390/biomedicines10071728 |2 doi |
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| 041 | _ | _ | |a English |
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| 100 | 1 | _ | |a Prasuhn, Jannik |0 0000-0003-4184-9409 |b 0 |
| 245 | _ | _ | |a Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy. |
| 260 | _ | _ | |a Basel |c 2022 |b MDPI |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (23Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) 23Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. 23Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP. |
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| 650 | _ | 7 | |a 23Na-MRI |2 Other |
| 650 | _ | 7 | |a PSP |2 Other |
| 650 | _ | 7 | |a heteronuclear MRI |2 Other |
| 650 | _ | 7 | |a neurodegeneration |2 Other |
| 650 | _ | 7 | |a progressive supranuclear palsy |2 Other |
| 700 | 1 | _ | |a Göttlich, Martin |b 1 |
| 700 | 1 | _ | |a Großer, Sinja S |b 2 |
| 700 | 1 | _ | |a Reuther, Katharina |b 3 |
| 700 | 1 | _ | |a Ebeling, Britt |b 4 |
| 700 | 1 | _ | |a Bodemann, Christina |b 5 |
| 700 | 1 | _ | |a Hanssen, Henrike |b 6 |
| 700 | 1 | _ | |a Nagel, Armin |0 P:(DE-He78)054fd7a5195b75b11fbdc5c360276011 |b 7 |u dkfz |
| 700 | 1 | _ | |a Brüggemann, Norbert |0 0000-0001-5969-6899 |b 8 |
| 773 | _ | _ | |a 10.3390/biomedicines10071728 |g Vol. 10, no. 7, p. 1728 - |0 PERI:(DE-600)2720867-9 |n 7 |p 1728 |t Biomedicines |v 10 |y 2022 |x 2227-9059 |
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