%0 Journal Article
%A Müller, Hans-Peter
%A Nagel, Armin
%A Keidel, Franziska
%A Wunderlich, Arthur
%A Hübers, Annemarie
%A Gast, Lena V.
%A Ludolph, Albert C.
%A Beer, Meinrad
%A Kassubek, Jan
%T Relaxation-weighted 23 Na magnetic resonance imaging maps regional patterns of abnormal sodium concentrations in amyotrophic lateral sclerosis
%J Therapeutic advances in chronic disease
%V 13
%@ 2040-6223
%C London
%I Sage
%M DKFZ-2022-01576
%P 20406223221109480
%D 2022
%Z #EA:E020# / 2022 Jul 8;13:20406223221109480 
%X Objectives: Multiparametric magnetic resonance imaging (MRI) is established as a technical instrument for the characterisation of patients with amyotrophic lateral sclerosis (ALS). The contribution of relaxation-weighted sodium ((NaR)-Na-23) MRI remains to be defined. The aim of this study is to apply (NaR)-Na-23 MRI to investigate brain sodium homeostasis and map potential alterations in patients with ALS as compared with healthy controls.Materials and Methods: Seventeen patients with ALS (mean age 61.1 +/- 11.4years, m/f=9/8) and 10 healthy control subjects (mean age 60.3 +/- 15.3years, m/f=6/4) were examined by (NaR)-Na-23 MRI at 3 T. Regional sodium maps were obtained by the calculation of the weighted difference from two image data sets with different echo times (TE1 = 0.3 ms, TE2 = 25 ms). Voxel-based analysis of the relaxation-weighted maps, together with Na-23 concentration maps for comparison, was performed.Results: ROI-based analyses of relaxation-weighted brain sodium concentration maps demonstrated increased sodium concentrations in the upper corticospinal tracts and in the frontal lobes in patients with ALS; no differences between ALS patients and controls were found in reference ROIs, where no involvement in ALS-associated neurodegeneration could be anticipated.Conclusion: (NaR)-Na-23 MRI mapped regional alterations within disease-relevant areas in ALS which correspond to the stages of the central nervous system (CNS) pathology, providing evidence that the technique is a potential biological marker of the cerebral neurodegenerative process in ALS.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35837670
%R 10.1177/20406223221109480
%U https://inrepo02.dkfz.de/record/180820