Journal Article

DKFZ-2022-01576

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Relaxation-weighted 23 Na magnetic resonance imaging maps regional patterns of abnormal sodium concentrations in amyotrophic lateral sclerosis

Müller, H.-P. ; Nagel, A. (First author)DKFZ* ; Keidel, F. ; Wunderlich, A. ; Hübers, A. ; Gast, L. V. ; Ludolph, A. C. ; Beer, M. ; Kassubek, J.

2022
Sage London

This record in other databases:  

Please use a persistent id in citations: doi:10.1177/20406223221109480

Abstract: Objectives: Multiparametric magnetic resonance imaging (MRI) is established as a technical instrument for the characterisation of patients with amyotrophic lateral sclerosis (ALS). The contribution of relaxation-weighted sodium ((NaR)-Na-23) MRI remains to be defined. The aim of this study is to apply (NaR)-Na-23 MRI to investigate brain sodium homeostasis and map potential alterations in patients with ALS as compared with healthy controls.Materials and Methods: Seventeen patients with ALS (mean age 61.1 +/- 11.4years, m/f=9/8) and 10 healthy control subjects (mean age 60.3 +/- 15.3years, m/f=6/4) were examined by (NaR)-Na-23 MRI at 3 T. Regional sodium maps were obtained by the calculation of the weighted difference from two image data sets with different echo times (TE1 = 0.3 ms, TE2 = 25 ms). Voxel-based analysis of the relaxation-weighted maps, together with Na-23 concentration maps for comparison, was performed.Results: ROI-based analyses of relaxation-weighted brain sodium concentration maps demonstrated increased sodium concentrations in the upper corticospinal tracts and in the frontal lobes in patients with ALS; no differences between ALS patients and controls were found in reference ROIs, where no involvement in ALS-associated neurodegeneration could be anticipated.Conclusion: (NaR)-Na-23 MRI mapped regional alterations within disease-relevant areas in ALS which correspond to the stages of the central nervous system (CNS) pathology, providing evidence that the technique is a potential biological marker of the cerebral neurodegenerative process in ALS.

Note: #EA:E020# / 2022 Jul 8;13:20406223221109480

---

Contributing Institute(s):

1. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2022

---

Database coverage:
; ; ; Article Processing Charges ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---