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000180820 1001_ $$aMüller, Hans-Peter$$b0
000180820 245__ $$aRelaxation-weighted 23 Na magnetic resonance imaging maps regional patterns of abnormal sodium concentrations in amyotrophic lateral sclerosis
000180820 260__ $$aLondon$$bSage$$c2022
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000180820 500__ $$a#EA:E020# / 2022 Jul 8;13:20406223221109480 
000180820 520__ $$aObjectives: Multiparametric magnetic resonance imaging (MRI) is established as a technical instrument for the characterisation of patients with amyotrophic lateral sclerosis (ALS). The contribution of relaxation-weighted sodium ((NaR)-Na-23) MRI remains to be defined. The aim of this study is to apply (NaR)-Na-23 MRI to investigate brain sodium homeostasis and map potential alterations in patients with ALS as compared with healthy controls.Materials and Methods: Seventeen patients with ALS (mean age 61.1 +/- 11.4years, m/f=9/8) and 10 healthy control subjects (mean age 60.3 +/- 15.3years, m/f=6/4) were examined by (NaR)-Na-23 MRI at 3 T. Regional sodium maps were obtained by the calculation of the weighted difference from two image data sets with different echo times (TE1 = 0.3 ms, TE2 = 25 ms). Voxel-based analysis of the relaxation-weighted maps, together with Na-23 concentration maps for comparison, was performed.Results: ROI-based analyses of relaxation-weighted brain sodium concentration maps demonstrated increased sodium concentrations in the upper corticospinal tracts and in the frontal lobes in patients with ALS; no differences between ALS patients and controls were found in reference ROIs, where no involvement in ALS-associated neurodegeneration could be anticipated.Conclusion: (NaR)-Na-23 MRI mapped regional alterations within disease-relevant areas in ALS which correspond to the stages of the central nervous system (CNS) pathology, providing evidence that the technique is a potential biological marker of the cerebral neurodegenerative process in ALS.
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000180820 7001_ $$0P:(DE-He78)054fd7a5195b75b11fbdc5c360276011$$aNagel, Armin$$b1$$eFirst author$$udkfz
000180820 7001_ $$aKeidel, Franziska$$b2
000180820 7001_ $$aWunderlich, Arthur$$b3
000180820 7001_ $$00000-0002-3088-0366$$aHübers, Annemarie$$b4
000180820 7001_ $$aGast, Lena V.$$b5
000180820 7001_ $$aLudolph, Albert C.$$b6
000180820 7001_ $$aBeer, Meinrad$$b7
000180820 7001_ $$00000-0002-7106-9270$$aKassubek, Jan$$b8
000180820 773__ $$0PERI:(DE-600)2554816-5$$a10.1177/20406223221109480$$gVol. 13, p. 204062232211094 -$$p20406223221109480$$tTherapeutic advances in chronic disease$$v13$$x2040-6223$$y2022
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