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000180823 041__ $$aEnglish
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000180823 1001_ $$00000-0002-4885-1168$$aRott, Jeremy$$b0
000180823 245__ $$aNutritional Calcium Supply Dependent Calcium Balance, Bone Calcification and Calcium Isotope Ratios in Rats.
000180823 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2022
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000180823 520__ $$aSerum calcium isotopes (δ44/42Ca) have been suggested as a non-invasive and sensitive Ca balance marker. Quantitative δ44/42Ca changes associated with Ca flux across body compartment barriers relative to the dietary Ca and the correlation of δ44/42CaSerum with bone histology are unknown. We analyzed Ca and δ44/42Ca by mass-spectrometry in rats after two weeks of standard-Ca-diet (0.5%) and after four subsequent weeks of standard- and of low-Ca-diet (0.25%). In animals on a low-Ca-diet net Ca gain was 61 ± 3% and femur Ca content 68 ± 41% of standard-Ca-diet, bone mineralized area per section area was 68 ± 15% compared to standard-Ca-diet. δ44/42Ca was similar in the diets, and decreased in feces and urine and increased in serum in animals on low-Ca-diet. δ44/42CaBone was higher in animals on low-Ca-diet, lower in the diaphysis than the metaphysis and epiphysis, and unaffected by gender. Independent of diet, δ44/42CaBone was similar in the femora and ribs. At the time of sacrifice, δ44/42CaSerum inversely correlated with intestinal Ca uptake and histological bone mineralization markers, but not with Ca content and bone mineral density by µCT. In conclusion, δ44/42CaBone was bone site specific, but mechanical stress and gender independent. Low-Ca-diet induced marked changes in feces, serum and urine δ44/42Ca in growing rats. δ44/42CaSerum inversely correlated with markers of bone mineralization.
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000180823 650_7 $$2Other$$abone mineralization
000180823 650_7 $$2Other$$acalcium
000180823 650_7 $$2Other$$acalcium deficiency
000180823 650_7 $$2Other$$afractionation
000180823 650_7 $$2Other$$aisotope
000180823 7001_ $$aToepfer, Eva Teresa$$b1
000180823 7001_ $$00000-0003-1127-3453$$aBartosova, Maria$$b2
000180823 7001_ $$aKolevica, Ana$$b3
000180823 7001_ $$00000-0003-3772-5534$$aHeuser, Alexander$$b4
000180823 7001_ $$aRabe, Michael$$b5
000180823 7001_ $$aBehets, Geert$$b6
000180823 7001_ $$00000-0003-1463-6571$$aD'Haese, Patrick C$$b7
000180823 7001_ $$0P:(DE-He78)1062e10961e437a74b9dd7542cd4ba7c$$aEichwald, Viktoria$$b8$$udkfz
000180823 7001_ $$0P:(DE-He78)f12dec7b80065347181cf69f8233b40d$$aJugold, Manfred$$b9$$udkfz
000180823 7001_ $$aDamgov, Ivan$$b10
000180823 7001_ $$00000-0002-3083-3244$$aZarogiannis, Sotirios G$$b11
000180823 7001_ $$00000-0001-8501-1072$$aShroff, Rukshana$$b12
000180823 7001_ $$aEisenhauer, Anton$$b13
000180823 7001_ $$00000-0003-4487-3332$$aSchmitt, Claus Peter$$b14
000180823 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms23147796$$gVol. 23, no. 14, p. 7796 -$$n14$$p7796$$tInternational journal of molecular sciences$$v23$$x1422-0067$$y2022
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