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@ARTICLE{Rott:180823,
      author       = {J. Rott and E. T. Toepfer and M. Bartosova and A. Kolevica
                      and A. Heuser and M. Rabe and G. Behets and P. C. D'Haese
                      and V. Eichwald$^*$ and M. Jugold$^*$ and I. Damgov and S.
                      G. Zarogiannis and R. Shroff and A. Eisenhauer and C. P.
                      Schmitt},
      title        = {{N}utritional {C}alcium {S}upply {D}ependent {C}alcium
                      {B}alance, {B}one {C}alcification and {C}alcium {I}sotope
                      {R}atios in {R}ats.},
      journal      = {International journal of molecular sciences},
      volume       = {23},
      number       = {14},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2022-01579},
      pages        = {7796},
      year         = {2022},
      note         = {2022 Jul 14;23(14):7796},
      abstract     = {Serum calcium isotopes (δ44/42Ca) have been suggested as a
                      non-invasive and sensitive Ca balance marker. Quantitative
                      δ44/42Ca changes associated with Ca flux across body
                      compartment barriers relative to the dietary Ca and the
                      correlation of δ44/42CaSerum with bone histology are
                      unknown. We analyzed Ca and δ44/42Ca by mass-spectrometry
                      in rats after two weeks of standard-Ca-diet $(0.5\%)$ and
                      after four subsequent weeks of standard- and of low-Ca-diet
                      $(0.25\%).$ In animals on a low-Ca-diet net Ca gain was 61
                      ± $3\%$ and femur Ca content 68 ± $41\%$ of
                      standard-Ca-diet, bone mineralized area per section area was
                      68 ± $15\%$ compared to standard-Ca-diet. δ44/42Ca was
                      similar in the diets, and decreased in feces and urine and
                      increased in serum in animals on low-Ca-diet. δ44/42CaBone
                      was higher in animals on low-Ca-diet, lower in the diaphysis
                      than the metaphysis and epiphysis, and unaffected by gender.
                      Independent of diet, δ44/42CaBone was similar in the femora
                      and ribs. At the time of sacrifice, δ44/42CaSerum inversely
                      correlated with intestinal Ca uptake and histological bone
                      mineralization markers, but not with Ca content and bone
                      mineral density by µCT. In conclusion, δ44/42CaBone was
                      bone site specific, but mechanical stress and gender
                      independent. Low-Ca-diet induced marked changes in feces,
                      serum and urine δ44/42Ca in growing rats. δ44/42CaSerum
                      inversely correlated with markers of bone mineralization.},
      keywords     = {bone mineralization (Other) / calcium (Other) / calcium
                      deficiency (Other) / fractionation (Other) / isotope
                      (Other)},
      cin          = {W240},
      ddc          = {540},
      cid          = {I:(DE-He78)W240-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35887143},
      doi          = {10.3390/ijms23147796},
      url          = {https://inrepo02.dkfz.de/record/180823},
}