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@ARTICLE{Kroupa:181307,
      author       = {M. Kroupa and K. Tomasova and M. Kavec and P. Skrobanek and
                      T. Buchler and R. Kumar$^*$ and L. Vodickova and P. Vodicka},
      title        = {{TE}lomeric repeat-containing {RNA} ({TERRA}):
                      {P}hysiological functions and relevance in cancer.},
      journal      = {Frontiers in oncology},
      volume       = {12},
      issn         = {2234-943X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2022-01934},
      pages        = {913314},
      year         = {2022},
      abstract     = {Telomeres are complex protective structures located at the
                      ends of linear eukaryotic chromosomes. Their purpose is to
                      prevent genomic instability. Research progress in telomere
                      biology during the past decades has identified a network of
                      telomeric transcripts of which the best-studied is TElomeric
                      Repeat-containing RNA (TERRA). TERRA was shown to be
                      important not only for the preservation of telomere
                      homeostasis and genomic stability but also for the
                      expression of hundreds of genes across the human genome.
                      These findings added a new level of complexity to telomere
                      biology. Herein we provide insights on the telomere
                      transcriptome, its relevance for proper telomere function,
                      and its implications in human pathology. We also discuss
                      possible clinical opportunities of exosomal telomere
                      transcripts detection as a biomarker in cancer precision
                      medicine.},
      subtyp        = {Review Article},
      keywords     = {Alternative lengthening of telomeres (Other) / TERRA
                      (Other) / cancer (Other) / long non-coding RNA (Other) /
                      telomere homeostasis (Other)},
      cin          = {B070 / C050},
      ddc          = {610},
      cid          = {I:(DE-He78)B070-20160331 / I:(DE-He78)C050-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35982970},
      pmc          = {pmc:PMC9380590},
      doi          = {10.3389/fonc.2022.913314},
      url          = {https://inrepo02.dkfz.de/record/181307},
}