Journal Article (Review Article)

DKFZ-2022-01934

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png TElomeric repeat-containing RNA (TERRA): Physiological functions and relevance in cancer.

Kroupa, M. ; Tomasova, K. ; Kavec, M. ; Skrobanek, P. ; Buchler, T. ; Kumar, R.DKFZ* ; Vodickova, L. ; Vodicka, P.

2022
Frontiers Media Lausanne

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Please use a persistent id in citations: doi:10.3389/fonc.2022.913314

Abstract: Telomeres are complex protective structures located at the ends of linear eukaryotic chromosomes. Their purpose is to prevent genomic instability. Research progress in telomere biology during the past decades has identified a network of telomeric transcripts of which the best-studied is TElomeric Repeat-containing RNA (TERRA). TERRA was shown to be important not only for the preservation of telomere homeostasis and genomic stability but also for the expression of hundreds of genes across the human genome. These findings added a new level of complexity to telomere biology. Herein we provide insights on the telomere transcriptome, its relevance for proper telomere function, and its implications in human pathology. We also discuss possible clinical opportunities of exosomal telomere transcripts detection as a biomarker in cancer precision medicine.

Keyword(s): Alternative lengthening of telomeres ; TERRA ; cancer ; long non-coding RNA ; telomere homeostasis

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Contributing Institute(s):

1. B070 Funktionelle Genomanalyse (B070)
2. Molekular-Genetische Epidemiologie (C050)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2022

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Database coverage:
; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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