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000181520 0247_ $$2doi$$a10.1007/s00066-022-01994-3
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000181520 0247_ $$2ISSN$$a1439-099X
000181520 037__ $$aDKFZ-2022-02055
000181520 041__ $$aEnglish
000181520 082__ $$a610
000181520 1001_ $$00000-0001-5231-9097$$aBernhardt, Denise$$b0
000181520 245__ $$aDEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis.
000181520 260__ $$aHeidelberg$$bSpringer Medizin$$c2022
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000181520 500__ $$a#EA:E050# / 2022 Oct;198(10):873-883
000181520 520__ $$aThe Working Group for Neuro-Oncology of the German Society for Radiation Oncology in cooperation with members of the Neuro-Oncology Working Group of the German Cancer Society aimed to define a practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS).Panel members of the DEGRO working group invited experts, participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for medical treatment of RN including bevacizumab in clinical routine.Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neuro-oncologist. A multistep approach as an opportunity to review as many characteristics as possible to improve diagnostic confidence is recommended. Additional information about radiotherapy (RT) techniques is crucial for the diagnosis of RN. Misdiagnosis of untreated and progressive RN can lead to severe neurological deficits. In this practice guideline, we propose a detailed nomenclature of treatment-related changes and a multistep approach for their diagnosis.
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000181520 650_7 $$2Other$$aBevacizumab
000181520 650_7 $$2Other$$aBrain metastases
000181520 650_7 $$2Other$$aGlioma
000181520 650_7 $$2Other$$aRadioation necrosis
000181520 650_7 $$2Other$$aReirradiation
000181520 7001_ $$0P:(DE-HGF)0$$aKönig, Laila$$b1$$eFirst author
000181520 7001_ $$0P:(DE-HGF)0$$aGrosu, Anca$$b2
000181520 7001_ $$aWiestler, Benedikt$$b3
000181520 7001_ $$aRieken, Stefan$$b4
000181520 7001_ $$0P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aWick, Wolfgang$$b5$$udkfz
000181520 7001_ $$aGempt, Jens$$b6
000181520 7001_ $$aKrieg, Sandro M$$b7
000181520 7001_ $$aSchmidt-Graf, Friederike$$b8
000181520 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b9$$udkfz
000181520 7001_ $$aMeyer, Bernhard$$b10
000181520 7001_ $$aKrause, Bernd J$$b11
000181520 7001_ $$aPetersen, Cordula$$b12
000181520 7001_ $$aFietkau, Rainer$$b13
000181520 7001_ $$aThomas, Michael$$b14
000181520 7001_ $$aGiordano, Frank$$b15
000181520 7001_ $$aWittig-Sauerwein, Andrea$$b16
000181520 7001_ $$0P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aDebus, Jürgen$$b17$$udkfz
000181520 7001_ $$aTabatabai, Ghazaleh$$b18
000181520 7001_ $$aHau, Peter$$b19
000181520 7001_ $$aSteinbach, Joachim$$b20
000181520 7001_ $$0P:(DE-HGF)0$$aCombs, Stephanie E$$b21
000181520 7001_ $$aOncology, Expert Panel of the German Society of Radiation$$b22$$eCollaboration Author
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