Journal Article (Review Article)

DKFZ-2022-02055

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png DEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis.

Bernhardt, D.DKFZ* ; König, L. (First author)DKFZ* ; Grosu, A.DKFZ* ; Wiestler, B. ; Rieken, S. ; Wick, W.DKFZ* ; Gempt, J. ; Krieg, S. M. ; Schmidt-Graf, F. ; Sahm, F.DKFZ* ; Meyer, B. ; Krause, B. J. ; Petersen, C. ; Fietkau, R. ; Thomas, M. ; Giordano, F. ; Wittig-Sauerwein, A. ; Debus, J.DKFZ* ; Tabatabai, G. ; Hau, P. ; Steinbach, J. ; Combs, S. E.DKFZ* ; Oncology, E. P. o. t. G. S. o. R. (Collaboration Author)

2022
Springer Medizin Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00066-022-01994-3

Abstract: The Working Group for Neuro-Oncology of the German Society for Radiation Oncology in cooperation with members of the Neuro-Oncology Working Group of the German Cancer Society aimed to define a practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS).Panel members of the DEGRO working group invited experts, participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for medical treatment of RN including bevacizumab in clinical routine.Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neuro-oncologist. A multistep approach as an opportunity to review as many characteristics as possible to improve diagnostic confidence is recommended. Additional information about radiotherapy (RT) techniques is crucial for the diagnosis of RN. Misdiagnosis of untreated and progressive RN can lead to severe neurological deficits. In this practice guideline, we propose a detailed nomenclature of treatment-related changes and a multistep approach for their diagnosis.

Keyword(s): Bevacizumab ; Brain metastases ; Glioma ; Radioation necrosis ; Reirradiation

Note: #EA:E050# / 2022 Oct;198(10):873-883

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Contributing Institute(s):

1. DKTK MU LMU zentral (MU01)
2. DKTK FR zentral (FR01)
3. DKTK HD zentral (HD01)
4. KKE Neuroonkologie (B320)
5. E050 KKE Strahlentherapie (E050)
6. KKE Neuropathologie (B300)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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