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@ARTICLE{Bernhardt:181520,
author = {D. Bernhardt$^*$ and L. König$^*$ and A. Grosu$^*$ and B.
Wiestler and S. Rieken and W. Wick$^*$ and J. Gempt and S.
M. Krieg and F. Schmidt-Graf and F. Sahm$^*$ and B. Meyer
and B. J. Krause and C. Petersen and R. Fietkau and M.
Thomas and F. Giordano and A. Wittig-Sauerwein and J.
Debus$^*$ and G. Tabatabai and P. Hau and J. Steinbach and
S. E. Combs$^*$},
collaboration = {E. P. o. t. G. S. o. R. Oncology},
title = {{DEGRO} practical guideline for central nervous system
radiation necrosis part 1: classification and a multistep
approach for diagnosis.},
journal = {Strahlentherapie und Onkologie},
volume = {198},
number = {10},
issn = {0179-7158},
address = {Heidelberg},
publisher = {Springer Medizin},
reportid = {DKFZ-2022-02055},
pages = {873-883},
year = {2022},
note = {#EA:E050# / 2022 Oct;198(10):873-883},
abstract = {The Working Group for Neuro-Oncology of the German Society
for Radiation Oncology in cooperation with members of the
Neuro-Oncology Working Group of the German Cancer Society
aimed to define a practical guideline for the diagnosis and
treatment of radiation-induced necrosis (RN) of the central
nervous system (CNS).Panel members of the DEGRO working
group invited experts, participated in a series of
conferences, supplemented their clinical experience,
performed a literature review, and formulated
recommendations for medical treatment of RN including
bevacizumab in clinical routine.Diagnosis and treatment of
RN requires multidisciplinary structures of care and defined
processes. Diagnosis has to be made on an interdisciplinary
level with the joint knowledge of a neuroradiologist,
radiation oncologist, neurosurgeon, neuropathologist, and
neuro-oncologist. A multistep approach as an opportunity to
review as many characteristics as possible to improve
diagnostic confidence is recommended. Additional information
about radiotherapy (RT) techniques is crucial for the
diagnosis of RN. Misdiagnosis of untreated and progressive
RN can lead to severe neurological deficits. In this
practice guideline, we propose a detailed nomenclature of
treatment-related changes and a multistep approach for their
diagnosis.},
subtyp = {Review Article},
keywords = {Bevacizumab (Other) / Brain metastases (Other) / Glioma
(Other) / Radioation necrosis (Other) / Reirradiation
(Other)},
cin = {MU01 / FR01 / HD01 / B320 / E050 / B300},
ddc = {610},
cid = {I:(DE-He78)MU01-20160331 / I:(DE-He78)FR01-20160331 /
I:(DE-He78)HD01-20160331 / I:(DE-He78)B320-20160331 /
I:(DE-He78)E050-20160331 / I:(DE-He78)B300-20160331},
pnm = {315 - Bildgebung und Radioonkologie (POF4-315)},
pid = {G:(DE-HGF)POF4-315},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:36038669},
doi = {10.1007/s00066-022-01994-3},
url = {https://inrepo02.dkfz.de/record/181520},
}