Journal Article

DKFZ-2022-02329

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The correlation between pre-treatment symptoms, acute and late toxicity and patient-reported health-related quality of life in non-small cell lung cancer patients: Results of the REQUITE study.

van der Weijst, L. ; Azria, D. ; Berkovic, P. ; Boisselier, P. ; Briers, E. ; Bultijnck, R. ; Chang-Claude, J.DKFZ* ; Choudhury, A. ; Defraene, G. ; Demontois, S. ; Elliott, R. M. ; Ennis, D. ; Faivre-Finn, C. ; Franceschini, M. ; Giandini, T. ; Giraldo, A. ; Gutiérrez-Enríquez, S. ; Herskind, C. ; Higginson, D. S. ; Kerns, S. L. ; Johnson, K. ; Lambrecht, M. ; Lang, P. ; Ramos, M. ; Rancati, T. ; Rimner, A. ; Rosenstein, B. S. ; De Ruysscher, D. ; Salem, A. ; Sangalli, C. ; Seibold, P.DKFZ* ; Sosa Fajardo, P. ; Sperk, E. ; Stobart, H. ; Summersgill, H. ; Surmont, V. ; Symonds, P. ; Taboada-Valladares, B. ; Talbot, C. J. ; Vega, A. ; Veldeman, L. ; Veldwijk, M. R. ; Ward, T. ; Webb, A. ; West, C. M. L. ; Lievens, Y. ; consortium, R. (Collaboration Author)

2022
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.radonc.2022.09.020

Abstract: To investigate the association between clinician-scored toxicities and patient-reported health-related quality of life (HRQoL), in early-stage (ES-) and locally-advanced (LA-) non-small cell lung cancer (NSCLC) patients receiving loco-regional radiotherapy, included in the international real-world REQUITE study.Clinicians scored eleven radiotherapy-related toxicities (and baseline symptoms) with the Common Terminology Criteria for Adverse Events version 4. HRQoL was assessed with the European Organization for Research and Treatment of Cancer core HRQoL questionnaire (EORTC-QLQ-C30). Statistical analyses used the mixed-model method; statistical significance was set at p=0.01. Analyses were performed for baseline and subsequent time points up to 2 years after radiotherapy and per treatment modality, radiotherapy technique and disease stage.Data of 435 patients were analysed. Pre-treatment, overall symptoms, dyspnea, chest wall pain, dysphagia and cough impacted overall HRQoL and specific domains. At subsequent time points, cough and dysphagia were overtaken by pericarditis in affecting HRQoL. Toxicities during concurrent chemo-radiotherapy and 3-dimensional radiotherapy had the most impact on HRQoL. Conversely, toxicities in sequential chemo-radiotherapy and SBRT had limited impact on patients' HRQoL. Stage impacts the correlations: LA-NSCLC patients are more adversely affected by toxicity than ES-NSCLC patients, mimicking the results of radiotherapy technique and treatment modality.Pre-treatment symptoms and acute/late toxicities variously impact HRQoL of ES- and LA-NSCLC patients undergoing different treatment approaches and radiotherapy techniques. Throughout the disease, dyspnea seems crucial in this association, highlighting the additional effect of co-existing comorbidities. Our data call for optimized radiotherapy limiting toxicities that may affect patients' HRQoL.

Keyword(s): Health-related quality of life ; association ; non-small cell lung cancer ; patient-reported outcomes ; radiotherapy ; technique ; toxicity

Note: 2022 Oct 3;176:127-137

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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