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| 001 | 182025 | ||
| 005 | 20241220120851.0 | ||
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| 100 | 1 | _ | |a Sha, Sha |0 P:(DE-He78)1d6f6305a65e2f7de2c7fbffbae83780 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Real-world evidence for the effectiveness of vitamin D supplementation in reduction of total and cause-specific mortality. |
| 260 | _ | _ | |a Oxford [u.a.] |c 2023 |b Wiley-Blackwell |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a #EA:C070#LA:C070# / 2023 Mar;293(3):384-397 |
| 520 | _ | _ | |a Meta-analyses of randomized controlled trials (RCTs) demonstrated the efficacy of vitamin D supplementation for reduced cancer mortality, all-cause mortality, and respiratory tract infections. However, whether and to what extent this translates into effectiveness in real-world practice is unknown.We assessed the association of vitamin D supplements use (as an over-the-counter drug or as part of a multivitamin product), vitamin D deficiency (25-hydroxyvitamin D (25(OH)D) < 30 nmol/L) and insufficiency (25(OH)D 30-<50 nmol/L) with all-cause and cause-specific mortality in 445,601 participants, aged 40-73 years, from the UK Biobank cohort.4.3% and further 20.4% of the study participants reported regularly taking vitamin D or multivitamin supplements, respectively. Still, the majority had either vitamin D deficiency (21.0%) or insufficiency (34.3%). We detected 49 independent determinants of vitamin D deficiency and vitamin D supplement use and used them to adjust Cox regression models for all mortality outcomes. 29,107 (6.5%) participants died during a median follow-up time of 11.8 years. Both vitamin D deficiency and insufficiency were strongly associated with all mortality outcomes. Self-reported vitamin D supplements use (83% over-the-counter/17% prescription drugs) and multivitamin intake were significantly associated with 10% and 5% lower all-cause mortality, respectively. Furthermore, regular vitamin D supplement users had 11%, 11% and 29% lower cancer, cardiovascular disease and respiratory disease mortality than non-users, respectively (not significant for cardiovascular disease mortality).This large study suggests that in the real world, the efficacy of vitamin D supplements in reducing mortality may be at least as good as observed in RCTs. This article is protected by copyright. All rights reserved. |
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| 650 | _ | 7 | |a Vitamin D |2 Other |
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| 700 | 1 | _ | |a Nguyen, Thi Mai Ngoc |0 P:(DE-He78)fe013930e5e3c95883704df32ae72bb4 |b 1 |u dkfz |
| 700 | 1 | _ | |a Kuznia, Sabine |0 P:(DE-He78)a1d1b323625dcfa155b477a646cbda52 |b 2 |u dkfz |
| 700 | 1 | _ | |a Niedermaier, Tobias |0 0000-0001-7990-3437 |b 3 |
| 700 | 1 | _ | |a Zhu, Anna |0 0000-0002-3432-0593 |b 4 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 5 |u dkfz |
| 700 | 1 | _ | |a Schöttker, Ben |0 0000-0002-1217-4521 |b 6 |e Last author |
| 773 | _ | _ | |a 10.1111/joim.13578 |g p. joim.13578 |0 PERI:(DE-600)2006883-9 |n 3 |p 384-397 |t Journal of internal medicine |v 293 |y 2023 |x 0001-6101 |
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