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000182101 041__ $$aEnglish
000182101 082__ $$a610
000182101 1001_ $$aMeyer, Antoine$$b0
000182101 245__ $$aFood processing and risk of Crohn's disease and ulcerative colitis: A European Prospective Cohort Study.
000182101 260__ $$aNew York, NY$$bElsevier Science$$c2023
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000182101 500__ $$a2023 Jun;21(6):1607-1616.e6
000182101 520__ $$aIndustrial foods have been associated with increased risks of several chronic conditions. We investigated the relation between degree of food processing, and risks of Crohn's disease (CD) and ulcerative colitis (UC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Analyses included 413,590 participants (68.6% women; mean baseline age 51.7 years) from eight European countries. Dietary data were collected at baseline from validated country-specific dietary questionnaires. Associations between proportions of unprocessed/minimally processed foods and of ultra-processed foods intake, and CD and UC risks were estimated using Cox models to obtain Hazards Ratios (HRs) and 95% confidence intervals (95%CIs). Models were stratified by centre, age, and sex, and adjusted for smoking status, BMI, physical activity, energy intake, educational level, and alcohol consumption.During a mean follow-up of 13.2 years, 179 incident cases of CD and 431 incident cases of UC were identified. The risk of CD was lower in people consuming high proportions of unprocessed/minimally processed foods (adjusted HR for the highest vs. lowest quartile: 0.57 (95%CI: 0.35-0.93; P-trend<0.01); particularly fruits and vegetables (adjusted HRs 0.54; 95%CI: 0.34-0.87 and 0.55; 95%CI: 0.34-0.91, respectively)). There was no association between unprocessed/minimally processed food intake and the risk of UC. No association was detected between ultra-processed foods consumption and CD or UC risks.In the EPIC cohort, consumption of unprocessed/minimally processed foods was associated with a lower risk of CD. No association between UC risk and food processing was found.
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000182101 650_7 $$2Other$$aCrohn’s disease
000182101 650_7 $$2Other$$aEPIC
000182101 650_7 $$2Other$$afood processing
000182101 650_7 $$2Other$$aulcerative colitis
000182101 7001_ $$aDong, Catherine$$b1
000182101 7001_ $$aCasagrande, Corinne$$b2
000182101 7001_ $$aChan, Simon$$b3
000182101 7001_ $$aHuybrechts, Inge$$b4
000182101 7001_ $$aNicolas, Geneviève$$b5
000182101 7001_ $$aRauber, Fernanda$$b6
000182101 7001_ $$aLevy, Renata Bertazzi$$b7
000182101 7001_ $$aMillett, Christopher$$b8
000182101 7001_ $$aOldenburg, Bas$$b9
000182101 7001_ $$aWeiderpass, Elisabete$$b10
000182101 7001_ $$aHeath, Alicia K$$b11
000182101 7001_ $$aTong, Tammy Yn$$b12
000182101 7001_ $$aTjønneland, Anne$$b13
000182101 7001_ $$aKyrø, Cecilie$$b14
000182101 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b15$$udkfz
000182101 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena A$$b16$$udkfz
000182101 7001_ $$aBergman, Manuela M$$b17
000182101 7001_ $$aPalli, Domenico$$b18
000182101 7001_ $$aMasala, Giovanna$$b19
000182101 7001_ $$aTumino, Rosario$$b20
000182101 7001_ $$aSacerdote, Carlotta$$b21
000182101 7001_ $$aColorado-Yohar, Sandra M$$b22
000182101 7001_ $$aSánchez, Maria-Jose$$b23
000182101 7001_ $$aGrip, Olof$$b24
000182101 7001_ $$aLindgren, Stefan$$b25
000182101 7001_ $$aLuben, Robert$$b26
000182101 7001_ $$aGunter, Marc J$$b27
000182101 7001_ $$aMahamat-Saleh, Yahya$$b28
000182101 7001_ $$aBoutron-Ruault, Marie-Christine$$b29
000182101 7001_ $$aCarbonnel, Franck$$b30
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