Journal Article

DKFZ-2022-02419

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Food processing and risk of Crohn's disease and ulcerative colitis: A European Prospective Cohort Study.

Meyer, A. ; Dong, C. ; Casagrande, C. ; Chan, S. ; Huybrechts, I. ; Nicolas, G. ; Rauber, F. ; Levy, R. B. ; Millett, C. ; Oldenburg, B. ; Weiderpass, E. ; Heath, A. K. ; Tong, T. Y. ; Tjønneland, A. ; Kyrø, C. ; Kaaks, R.DKFZ* ; Katzke, V. A.DKFZ* ; Bergman, M. M. ; Palli, D. ; Masala, G. ; Tumino, R. ; Sacerdote, C. ; Colorado-Yohar, S. M. ; Sánchez, M.-J. ; Grip, O. ; Lindgren, S. ; Luben, R. ; Gunter, M. J. ; Mahamat-Saleh, Y. ; Boutron-Ruault, M.-C. ; Carbonnel, F.

2023
Elsevier Science New York, NY

This record in other databases:  

Please use a persistent id in citations: doi:10.1016/j.cgh.2022.09.031

Abstract: Industrial foods have been associated with increased risks of several chronic conditions. We investigated the relation between degree of food processing, and risks of Crohn's disease (CD) and ulcerative colitis (UC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Analyses included 413,590 participants (68.6% women; mean baseline age 51.7 years) from eight European countries. Dietary data were collected at baseline from validated country-specific dietary questionnaires. Associations between proportions of unprocessed/minimally processed foods and of ultra-processed foods intake, and CD and UC risks were estimated using Cox models to obtain Hazards Ratios (HRs) and 95% confidence intervals (95%CIs). Models were stratified by centre, age, and sex, and adjusted for smoking status, BMI, physical activity, energy intake, educational level, and alcohol consumption.During a mean follow-up of 13.2 years, 179 incident cases of CD and 431 incident cases of UC were identified. The risk of CD was lower in people consuming high proportions of unprocessed/minimally processed foods (adjusted HR for the highest vs. lowest quartile: 0.57 (95%CI: 0.35-0.93; P-trend<0.01); particularly fruits and vegetables (adjusted HRs 0.54; 95%CI: 0.34-0.87 and 0.55; 95%CI: 0.34-0.91, respectively)). There was no association between unprocessed/minimally processed food intake and the risk of UC. No association was detected between ultra-processed foods consumption and CD or UC risks.In the EPIC cohort, consumption of unprocessed/minimally processed foods was associated with a lower risk of CD. No association between UC risk and food processing was found.

Keyword(s): Crohn’s disease ; EPIC ; food processing ; ulcerative colitis

Note: 2023 Jun;21(6):1607-1616.e6

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2022

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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