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000182184 1001_ $$0P:(DE-He78)f05eabc961bc296c088b3510d6429d02$$aMadi, Alaa Abdelghani Mohamed$$b0$$eFirst author$$udkfz
000182184 245__ $$aRegulatory T cell-derived interleukin-15 promotes the diversity of immunological memory.
000182184 260__ $$aWeinheim$$bWiley-VCH$$c2023
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000182184 520__ $$aWhile the immunosuppressive function of regulatory T (Treg) cells has been extensively studied, their immune-supportive roles have been less well investigated. Using a lymphocytic choriomeningitis virus (LCMV) Armstrong infection mouse model, we found that Treg cell-derived interleukin (IL)-15 is required for long-term maintenance of the KLRG1+ IL-7Rα- CD62L- terminal effector memory CD8+ T (tTEM) cell subset, but dispensable for the suppressive function of Treg cells themselves. In contrast, deletion of Il15 from other sources, including myeloid cells and muscles, did not affect the composition of the memory CD8+ T cell pool. Our findings identify Treg cells as an essential IL-15 source maintaining tTEM cells and suggest that Treg cells promote the diversity of immunological memory. This article is protected by copyright. All rights reserved.
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000182184 650_7 $$2Other$$aIL-15 ⋅ Treg cells ⋅ Effector memory ⋅ T cells
000182184 7001_ $$0P:(DE-He78)bf88e5f49a614f52ba8ce2cd433e6b41$$aWu, Jingxia$$b1$$udkfz
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000182184 7001_ $$0P:(DE-He78)32b6d84a1ad5f50401b97559993ad65d$$aMieg, Alessa$$b4$$udkfz
000182184 7001_ $$0P:(DE-He78)b099c4255c1bff642f4d338ef157596e$$aHering, Marvin$$b5$$udkfz
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000182184 7001_ $$0P:(DE-He78)0b7ce76033a6756b91f5bfb12602e20b$$aCui, Guoliang$$b12$$eLast author$$udkfz
000182184 773__ $$0PERI:(DE-600)1491907-2$$a10.1002/eji.202149400$$gp. eji.202149400$$n1$$pe2149400$$tEuropean journal of immunology$$v53$$x0014-2980$$y2023
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