Journal Article

DKFZ-2022-02486

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Regulatory T cell-derived interleukin-15 promotes the diversity of immunological memory.

Madi, A. A. M. (First author)DKFZ* ; Wu, J.DKFZ* ; Ma, S.DKFZ* ; Weisshaar, N.DKFZ* ; Mieg, A.DKFZ* ; Hering, M.DKFZ* ; Ming, Y.DKFZ* ; Zettl, F.DKFZ* ; Mohr, K.DKFZ* ; Ten Bosch, N.DKFZ* ; Schlimbach, T.DKFZ* ; Hertel, F.DKFZ* ; Cui, G. (Last author)DKFZ*

2023
Wiley-VCH Weinheim

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Please use a persistent id in citations: doi:10.1002/eji.202149400

Abstract: While the immunosuppressive function of regulatory T (Treg) cells has been extensively studied, their immune-supportive roles have been less well investigated. Using a lymphocytic choriomeningitis virus (LCMV) Armstrong infection mouse model, we found that Treg cell-derived interleukin (IL)-15 is required for long-term maintenance of the KLRG1+ IL-7Rα- CD62L- terminal effector memory CD8+ T (tTEM) cell subset, but dispensable for the suppressive function of Treg cells themselves. In contrast, deletion of Il15 from other sources, including myeloid cells and muscles, did not affect the composition of the memory CD8+ T cell pool. Our findings identify Treg cells as an essential IL-15 source maintaining tTEM cells and suggest that Treg cells promote the diversity of immunological memory. This article is protected by copyright. All rights reserved.

Keyword(s): IL-15 ⋅ Treg cells ⋅ Effector memory ⋅ T cells

Note: #EA:D192#LA:D192# / 2023 Jan;53(1):e2149400 / HI-TRON

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Contributing Institute(s):

1. T-Zell-Metabolismus (D192)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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