TY  - JOUR
AU  - Madi, Alaa Abdelghani Mohamed
AU  - Wu, Jingxia
AU  - Ma, Sicong
AU  - Weisshaar, Nina
AU  - Mieg, Alessa
AU  - Hering, Marvin
AU  - Ming, Yanan
AU  - Zettl, Ferdinand
AU  - Mohr, Kerstin
AU  - Ten Bosch, Nora
AU  - Schlimbach, Tilo
AU  - Hertel, Franziska
AU  - Cui, Guoliang
TI  - Regulatory T cell-derived interleukin-15 promotes the diversity of immunological memory.
JO  - European journal of immunology
VL  - 53
IS  - 1
SN  - 0014-2980
CY  - Weinheim
PB  - Wiley-VCH
M1  - DKFZ-2022-02486
SP  - e2149400
PY  - 2023
N1  - #EA:D192#LA:D192# / 2023 Jan;53(1):e2149400 / HI-TRON
AB  - While the immunosuppressive function of regulatory T (Treg) cells has been extensively studied, their immune-supportive roles have been less well investigated. Using a lymphocytic choriomeningitis virus (LCMV) Armstrong infection mouse model, we found that Treg cell-derived interleukin (IL)-15 is required for long-term maintenance of the KLRG1+ IL-7Rα- CD62L- terminal effector memory CD8+ T (tTEM) cell subset, but dispensable for the suppressive function of Treg cells themselves. In contrast, deletion of Il15 from other sources, including myeloid cells and muscles, did not affect the composition of the memory CD8+ T cell pool. Our findings identify Treg cells as an essential IL-15 source maintaining tTEM cells and suggest that Treg cells promote the diversity of immunological memory. This article is protected by copyright. All rights reserved.
KW  - IL-15 ⋅ Treg cells ⋅ Effector memory ⋅ T cells (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36263815
DO  - DOI:10.1002/eji.202149400
UR  - https://inrepo02.dkfz.de/record/182184
ER  -