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@ARTICLE{Madi:182184,
      author       = {A. A. M. Madi$^*$ and J. Wu$^*$ and S. Ma$^*$ and N.
                      Weisshaar$^*$ and A. Mieg$^*$ and M. Hering$^*$ and Y.
                      Ming$^*$ and F. Zettl$^*$ and K. Mohr$^*$ and N. Ten
                      Bosch$^*$ and T. Schlimbach$^*$ and F. Hertel$^*$ and G.
                      Cui$^*$},
      title        = {{R}egulatory {T} cell-derived interleukin-15 promotes the
                      diversity of immunological memory.},
      journal      = {European journal of immunology},
      volume       = {53},
      number       = {1},
      issn         = {0014-2980},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {DKFZ-2022-02486},
      pages        = {e2149400},
      year         = {2023},
      note         = {#EA:D192#LA:D192# / 2023 Jan;53(1):e2149400 / HI-TRON},
      abstract     = {While the immunosuppressive function of regulatory T (Treg)
                      cells has been extensively studied, their immune-supportive
                      roles have been less well investigated. Using a lymphocytic
                      choriomeningitis virus (LCMV) Armstrong infection mouse
                      model, we found that Treg cell-derived interleukin (IL)-15
                      is required for long-term maintenance of the KLRG1+ IL-7Rα-
                      CD62L- terminal effector memory CD8+ T (tTEM) cell subset,
                      but dispensable for the suppressive function of Treg cells
                      themselves. In contrast, deletion of Il15 from other
                      sources, including myeloid cells and muscles, did not affect
                      the composition of the memory CD8+ T cell pool. Our findings
                      identify Treg cells as an essential IL-15 source maintaining
                      tTEM cells and suggest that Treg cells promote the diversity
                      of immunological memory. This article is protected by
                      copyright. All rights reserved.},
      keywords     = {IL-15 ⋅ Treg cells ⋅ Effector memory ⋅ T cells
                      (Other)},
      cin          = {D192},
      ddc          = {610},
      cid          = {I:(DE-He78)D192-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36263815},
      doi          = {10.1002/eji.202149400},
      url          = {https://inrepo02.dkfz.de/record/182184},
}