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@ARTICLE{Wifeld:182203,
      author       = {J. Wißfeld$^*$ and A. Werner$^*$ and X. Yan$^*$ and N. Ten
                      Bosch$^*$ and G. Cui$^*$},
      title        = {{M}etabolic regulation of immune responses to cancer.},
      journal      = {Cancer biology $\&$ medicine},
      volume       = {29},
      number       = {11},
      issn         = {2095-3941},
      address      = {Tianjin},
      publisher    = {Medical Univ. Cancer Inst. $\&$ Hospital},
      reportid     = {DKFZ-2022-02497},
      pages        = {1528-1542},
      year         = {2022},
      note         = {#EA:D192#LA:D192# / 2022 Oct 24;19(11):1528-1542 / HI-TRON},
      abstract     = {The tumor microenvironment is an ecosystem composed of
                      multiple types of cells, such as tumor cells, immune cells,
                      and cancer-associated fibroblasts. Cancer cells grow faster
                      than non-cancerous cells and consume larger amounts of
                      nutrients. The rapid growth characteristic of cancer cells
                      fundamentally alters nutrient availability in the tumor
                      microenvironment and results in reprogramming of immune cell
                      metabolic pathways. Accumulating evidence suggests that
                      cellular metabolism of nutrients, such as lipids and amino
                      acids, beyond being essential to meet the bioenergetic and
                      biosynthetic demands of immune cells, also regulates a broad
                      spectrum of cellular signal transduction, and influences
                      immune cell survival, differentiation, and anti-tumor
                      effector function. The cancer immunometabolism research
                      field is rapidly evolving, and exciting new discoveries are
                      reported in high-profile journals nearly weekly. Therefore,
                      all new findings in this field cannot be summarized within
                      this short review. Instead, this review is intended to
                      provide a brief introduction to this rapidly developing
                      research field, with a focus on the metabolism of two
                      classes of important nutrients-lipids and amino acids-in
                      immune cells. We highlight recent research on the roles of
                      lipids and amino acids in regulating the metabolic fitness
                      and immunological functions of T cells, macrophages, and
                      natural killer cells in the tumor microenvironment.
                      Furthermore, we discuss the possibility of 'editing'
                      metabolic pathways in immune cells to act synergistically
                      with currently available immunotherapies in enhancing
                      anti-tumor immune responses.},
      subtyp        = {Review Article},
      keywords     = {Lipids (Other) / NK cells (Other) / T cells (Other) / amino
                      acids (Other) / anti-tumor immunity (Other) / cancer (Other)
                      / immunometabolism (Other) / metabolism (Other)},
      cin          = {D192},
      ddc          = {610},
      cid          = {I:(DE-He78)D192-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36269001},
      doi          = {10.20892/j.issn.2095-3941.2022.0381},
      url          = {https://inrepo02.dkfz.de/record/182203},
}