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000182368 0247_ $$2doi$$a10.1083/jcb.202203081
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000182368 0247_ $$2ISSN$$a0021-9525
000182368 0247_ $$2ISSN$$a0095-9901
000182368 0247_ $$2ISSN$$a1540-8140
000182368 0247_ $$2ISSN$$a2327-7440
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000182368 037__ $$aDKFZ-2022-02607
000182368 041__ $$aEnglish
000182368 082__ $$a570
000182368 1001_ $$aKarasu, Onur Rojhat$$b0
000182368 245__ $$aThe central scaffold protein CEP350 coordinates centriole length, stability, and maturation.
000182368 260__ $$aNew York, NY$$bRockefeller Univ. Press$$c2022
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000182368 520__ $$aThe centriole is the microtubule-based backbone that ensures integrity, function, and cell cycle-dependent duplication of centrosomes. Mostly unclear mechanisms control structural integrity of centrioles. Here, we show that the centrosome protein CEP350 functions as scaffold that coordinates distal-end properties of centrioles such as length, stability, and formation of distal and subdistal appendages. CEP350 fulfills these diverse functions by ensuring centriolar localization of WDR90, recruiting the proteins CEP78 and OFD1 to the distal end of centrioles and promoting the assembly of subdistal appendages that have a role in removing the daughter-specific protein Centrobin. The CEP350-FOP complex in association with CEP78 or OFD1 controls centriole microtubule length. Centrobin safeguards centriole distal end stability, especially in the compromised CEP350-/- cells, while the CEP350-FOP-WDR90 axis secures centriole integrity. This study identifies CEP350 as a guardian of the distal-end region of centrioles without having an impact on the proximal PCM part.
000182368 536__ $$0G:(DE-HGF)POF4-311$$a311 - Zellbiologie und Tumorbiologie (POF4-311)$$cPOF4-311$$fPOF IV$$x0
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000182368 650_7 $$2NLM Chemicals$$aCell Cycle Proteins
000182368 650_7 $$2NLM Chemicals$$aMicrotubule-Associated Proteins
000182368 650_2 $$2MeSH$$aCentrioles: metabolism
000182368 650_2 $$2MeSH$$aCell Cycle Proteins: genetics
000182368 650_2 $$2MeSH$$aCell Cycle Proteins: metabolism
000182368 650_2 $$2MeSH$$aMicrotubule-Associated Proteins: genetics
000182368 650_2 $$2MeSH$$aMicrotubule-Associated Proteins: metabolism
000182368 650_2 $$2MeSH$$aCentrosome: metabolism
000182368 650_2 $$2MeSH$$aMicrotubules: genetics
000182368 650_2 $$2MeSH$$aMicrotubules: metabolism
000182368 7001_ $$aNeuner, Annett$$b1
000182368 7001_ $$aAtorino, Enrico Salvatore$$b2
000182368 7001_ $$0P:(DE-He78)5138c10dcd0901d001d67a31423402b5$$aPereira, Gislene$$b3$$udkfz
000182368 7001_ $$00000-0002-3683-247X$$aSchiebel, Elmar$$b4
000182368 773__ $$0PERI:(DE-600)1421310-2$$a10.1083/jcb.202203081$$gVol. 221, no. 12, p. e202203081$$n12$$pe202203081$$tThe journal of cell biology$$v221$$x0021-9525$$y2022
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000182368 9141_ $$y2022
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