% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Karasu:182368,
      author       = {O. R. Karasu and A. Neuner and E. S. Atorino and G.
                      Pereira$^*$ and E. Schiebel},
      title        = {{T}he central scaffold protein {CEP}350 coordinates
                      centriole length, stability, and maturation.},
      journal      = {The journal of cell biology},
      volume       = {221},
      number       = {12},
      issn         = {0021-9525},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {DKFZ-2022-02607},
      pages        = {e202203081},
      year         = {2022},
      note         = {DKFZ-ZMBH Alliance},
      abstract     = {The centriole is the microtubule-based backbone that
                      ensures integrity, function, and cell cycle-dependent
                      duplication of centrosomes. Mostly unclear mechanisms
                      control structural integrity of centrioles. Here, we show
                      that the centrosome protein CEP350 functions as scaffold
                      that coordinates distal-end properties of centrioles such as
                      length, stability, and formation of distal and subdistal
                      appendages. CEP350 fulfills these diverse functions by
                      ensuring centriolar localization of WDR90, recruiting the
                      proteins CEP78 and OFD1 to the distal end of centrioles and
                      promoting the assembly of subdistal appendages that have a
                      role in removing the daughter-specific protein Centrobin.
                      The CEP350-FOP complex in association with CEP78 or OFD1
                      controls centriole microtubule length. Centrobin safeguards
                      centriole distal end stability, especially in the
                      compromised CEP350-/- cells, while the CEP350-FOP-WDR90 axis
                      secures centriole integrity. This study identifies CEP350 as
                      a guardian of the distal-end region of centrioles without
                      having an impact on the proximal PCM part.},
      keywords     = {Centrioles: metabolism / Cell Cycle Proteins: genetics /
                      Cell Cycle Proteins: metabolism / Microtubule-Associated
                      Proteins: genetics / Microtubule-Associated Proteins:
                      metabolism / Centrosome: metabolism / Microtubules: genetics
                      / Microtubules: metabolism / Cell Cycle Proteins (NLM
                      Chemicals) / Microtubule-Associated Proteins (NLM
                      Chemicals)},
      cin          = {A180},
      ddc          = {570},
      cid          = {I:(DE-He78)A180-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36315013},
      doi          = {10.1083/jcb.202203081},
      url          = {https://inrepo02.dkfz.de/record/182368},
}