000182522 001__ 182522
000182522 005__ 20240229145721.0
000182522 037__ $$aDKFZ-2022-02714
000182522 1001_ $$0P:(DE-HGF)0$$aThai, Long-Yang Han$$b0
000182522 245__ $$aX-Ray Minibeams - Dosimetry And In Vitro Effects OnH460 Lung Cancer Cells
000182522 260__ $$c2022
000182522 3367_ $$2DRIVER$$abachelorThesis
000182522 3367_ $$02$$2EndNote$$aThesis
000182522 3367_ $$2DataCite$$aOutput Types/Supervised Student Publication
000182522 3367_ $$0PUB:(DE-HGF)2$$2PUB:(DE-HGF)$$aBachelor Thesis$$bbachelor$$mbachelor$$s1668415832_22118
000182522 3367_ $$2BibTeX$$aMASTERSTHESIS
000182522 3367_ $$2ORCID$$aSUPERVISED_STUDENT_PUBLICATION
000182522 502__ $$aBachelorarbeit, Universität Heidelberg, 2022$$bBachelorarbeit$$cUniversität Heidelberg$$gFakultät für Physik und Astronomie
000182522 520__ $$aRadiotherapy can be used to treat cancer. The aim is to utilize the therapeutic window to killcancer cells efficiently while sparing surrounding healthy tissue as much as possible. Oneapproach that already reduces complications in vivo is the so-called minibeam radiotherapy.The spatially alternating dose maxima and minima are designed to allow significantly moreeffective tumor control compared to conventional broad dose distribution. This thesis comprisesa collimator study which investigated various collimator models and settings to generate x-rayminibeams of best possible quality. Diverse investigations and adjustments made it possible todevelop an optimal setup. With the help of appropriate dosimetric preparations, two largerin vitro studies with H460 lung cancer cells were conducted. A volume study investigatedwhether cells which received the same dose are damaged differently depending on the amountof medium or DPBS volumes they are covered in. The dose study, on the other hand, aimedto investigate the difference between conventional and minibeam irradiation. A variety ofexperiments have been carried out for both studies. One experiment showed the differencebetween homogeneous and minibeam irradiation
000182522 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000182522 909CO $$ooai:inrepo02.dkfz.de:182522$$pVDB
000182522 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000182522 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000182522 9141_ $$y2022
000182522 9201_ $$0I:(DE-He78)E041-20160331$$kE041$$lE041 Med. Physik in der Radioonkologie$$x0
000182522 980__ $$abachelor
000182522 980__ $$aVDB
000182522 980__ $$aI:(DE-He78)E041-20160331
000182522 980__ $$aUNRESTRICTED